Cell surface complement regulators moderate experimental myasthenia gravis pathology.
Cell surface complement regulators moderate experimental myasthenia gravis pathology.
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DOI：
10.1002/mus.23448
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发表时间：
2013-01
期刊：
影响因子：
3.4
通讯作者：
Kaminski, Henry J.
中科院分区：
文献类型：
--
作者：
Kusner, Linda L.;Halperin, Jose A.;Kaminski, Henry J.
Intrinsic mouse complement regulators influence the severity of passively induced experimental acquired myasthenia gravis (EAMG). To assess the potential influence of CD59b in the absence of CD59a background, we used the mCD59ab−/− mouse model to re-evaluate mCD59 in protecting the neuromuscular junction (NMJ). EAMG was induced with monoclonal antibody to the acetylcholine receptor (AChR) in Daf1−/−, CD59ab−/−, Daf1−/− CD59ab−/−, and wild-type C57Bl/6 mice. Animals were monitored throughout the experiment. Diaphragms were analyzed for NMJ injury. Daf1−/− CD59ab−/− mice required euthanasia 24 hours after disease induction because of severe weakness. Histological assessment demonstrated reduced AChR density, simplification of synaptic folds, and disrupted mitochondria. CD59ab-deficient mice demonstrated mild weakness and reduction in weight after 24 hours. In contrast, Daf1−/− had more severe weakness at 60 hours. The NMJ of EAMG-induced Daf1−/− and CD59ab−/− mice demonstrated similar AChR density. NMJs of CD59 and DAF mice are protected from complement-mediated injury of passive EAMG.
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DOI：
10.1084/jem.181.1.151
发表时间：
1995-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kim YU;Kinoshita T;Molina H;Hourcade D;Seya T;Wagner LM;Holers VM
通讯作者：
Holers VM
影响因子：
3.5
作者：
Gomez, Alejandro M.;Van den Broeck, Joost;Losen, Mario
通讯作者：
Losen, Mario
影响因子：
11
作者：
ENGEL, AG
通讯作者：
ENGEL, AG
影响因子：
6.4
作者：
Lin, F;Fukuoka, Y;Medof, ME
通讯作者：
Medof, ME
影响因子：
3.8
作者：
Hafer-Macko, CE;Dyck, PJ;Koski, CL
通讯作者：
Koski, CL