ANTIVIRAL ACTIVITY AND METABOLISM OF THE CASTANOSPERMINE DERIVATIVE MDL-28,574, IN CELLS INFECTED WITH HERPES-SIMPLEX VIRUS TYPE-2
ANTIVIRAL ACTIVITY AND METABOLISM OF THE CASTANOSPERMINE DERIVATIVE MDL-28,574, IN CELLS INFECTED WITH HERPES-SIMPLEX VIRUS TYPE-2
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DOI：
10.1006/bbrc.1995.1333
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发表时间：
1995-03-08
影响因子：
3.1
通讯作者：
TYMS, AS
中科院分区：
文献类型：
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作者：
AHMED, SP;NASH, RJ;TYMS, AS
castanospermine的6- o -丁烷基衍生物（MDL 28,574: BUCAST）是一种糖蛋白加工抑制剂，可阻断2型单纯疱疹病毒的生长，并且在感染前和感染后将细胞暴露于该化合物中，其效果显著增强。该衍生物的有效性与病毒感染后吸收增加和积累最大相对应。气相色谱/质谱分析鉴定MDL 28,574处理细胞的主要成分为castanospermine，一种α -葡萄糖苷酶1的抑制剂。该化合物对病毒糖蛋白gB合成的影响是通过增加富含甘露糖前体的分子量来确定的，这是糖蛋白加工调节的证据。(C) 1995学术出版社，Inc。
The 6-O-butanoyl derivative of castanospermine (MDL 28,574: BUCAST), an inhibitor of glycoprotein processing, blocked the growth of herpes simplex virus type-2 with the effect markedly enhanced by exposure of cells to the compound pre- as well as post-infection. The effectiveness of the derivative corresponded to an increased uptake with greatest accumulation after virus infection. Gas chromatography/mass spectrometry identified the predominant component in MDL 28,574 treated cells as castanospermine, an inhibitor of alpha-glucosidase 1. The effects of this compound on the synthesis of viral glycoprotein, gB, was determined with the increased molecular weight of the mannose-rich precursor evidence for the modulation of glycoprotein processing. (C) 1995 Academic Press, Inc.