Interaction of carbamylated LDL with LOX-1 in the induction of endothelial dysfunction and atherosclerosis.
Interaction of carbamylated LDL with LOX-1 in the induction of endothelial dysfunction and atherosclerosis.
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DOI：
10.1093/eurheartj/ehu122
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发表时间：
2014-11
影响因子：
39.3
通讯作者：
J. Mehta;A. Basnakian
中科院分区：
文献类型：
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作者：
J. Mehta;A. Basnakian
这篇社论提到T. Speer等人，第3021页尿素是人血浆的正常成分，但不是惰性的。LDL-胆固醇的脲源性氰酸酯修饰（称为LDL氨甲酰化）已经讨论了十多年。1最近的研究将LDL氨甲酰化与尿毒症患者和慢性肾病（CKD）动物的动脉粥样硬化联系起来。2 -4更广泛地说，蛋白氨甲酰化与CKD中的动脉粥样硬化性心血管疾病（CVD）有关。5氨甲酰化LDL（cLDL）诱导的内皮细胞（EC）功能障碍这似乎是CKD中CVD发生率高的合理解释。6然而，尽管在确定cLDL诱导的动脉粥样硬化的机制基础方面做出了相当大的努力，但这种联系仍然模糊，因为很难将基于体外、体内和独立进行的临床研究的复杂事件联系起来。施佩尔及其同事的一个重要贡献是，他们能够将所有这些方法联合收割机结合成一个统一的概念。与许多以前的研究不同，这些研究使用氰酸钾人工氨甲酰化的LDL，或测量蛋白质氨甲酰化，或通过酶联免疫吸附测定（ELISA）测量血浆cLDL，[1]：#fn-2
This editorial refers to ‘Carbamylated low-density lipoprotein induces endothelial dysfunction’[†][1], by T. Speer et al ., on page 3021. Urea is a normal component of human blood plasma, but it is not inert. Urea-derived cyanate modification of LDL-cholesterol, known as LDL carbamylation, has been discussed for more than a decade.1 Recent studies have linked LDL carbamylation to atherosclerosis in uraemic patients and animals with chronic kidney disease (CKD).2–4 More broadly, protein carbamylation has been linked with atherosclerotic cardiovascular disease (CVD) in CKD.5 Endothelial cell (EC) dysfunction induced by carbamylated LDL (cLDL) seems to be a plausible explanation for the high frequency of CVD in CKD.6 However, despite considerable efforts in determining the mechanistic basis of atherosclerosis induced by cLDL, the link remains blurry since it is hard to relate the complex events based on in vitro , in vivo , and clinical studies done independently. An important contribution by Speer and associates7 is that they were able to combine all these approaches into a unified concept. As opposed to many previous studies which used LDL artificially carbamylated by potassium cyanate, or measured protein carbamylation, or measured plasma cLDL by enzyme-linked immunosorbent assay (ELISA), … [1]: #fn-2