The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
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DOI：
10.1038/nature09142
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发表时间：
2010-07-01
期刊：
影响因子：
64.8
通讯作者：
Touhara, Kazushige
中科院分区：
文献类型：
--
作者：
Haga, Sachiko;Hattori, Tatsuya;Touhara, Kazushige
小鼠的多种社会行为受到被称为信息素的化学信号的调控，这些信息素通过犁鼻系统发挥作用（1 - 3）。外分泌腺分泌肽1（ESP1）是一种7 - kDa的肽，它被释放到雄性泪液中，并刺激雌性小鼠的犁鼻感觉神经元（4）。在此，我们描述了犁鼻系统中参与ESP1信号解码的分子和神经机制，这种解码导致雌性小鼠产生行为输出。ESP1可被一种特定的犁鼻受体V2Rp5识别，配体 - 受体相互作用导致性别特异性信号通过副嗅球传递到杏仁核和下丘脑核。因此，ESP1在雄性爬跨（脊柱前凸）时增强雌性的性接受行为，从而使交配成功。在V2Rp5缺陷型小鼠中，ESP1既不诱导神经激活也不诱导性行为。这些发现表明，ESP1是一种关键的雄性信息素，它通过小鼠犁鼻系统中的一种特定受体调节雌性生殖行为。
Various social behaviours in mice are regulated by chemical signals called pheromones that act through the vomeronasal system(1-3). Exocrine gland-secreting peptide 1 (ESP1) is a 7-kDa peptide that is released intomale tear fluids and stimulates vomeronasal sensory neurons in female mice(4). Here, we describe the molecular and neural mechanisms that are involved in the decoding of ESP1 signals in the vomeronasal system, which leads to behavioural output in female mice. ESP1 is recognized by a specific vomeronasal receptor, V2Rp5, and the ligand-receptor interaction results in sex-specific signal transmission to the amygdaloid and hypothalamic nuclei via the accessory olfactory bulb. Consequently, ESP1 enhances female sexual receptive behaviour upon male mounting (lordosis), allowing successful copulation. In V2Rp5-deficient mice, ESP1 induces neither neural activation nor sexual behaviour. These findings show that ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system.