SUGAR, MEAT, AND FAT INTAKE, AND NONDIETARY RISK-FACTORS FOR COLON-CANCER INCIDENCE IN IOWA WOMEN (UNITED-STATES)
SUGAR, MEAT, AND FAT INTAKE, AND NONDIETARY RISK-FACTORS FOR COLON-CANCER INCIDENCE IN IOWA WOMEN (UNITED-STATES)
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DOI：
10.1007/bf01830725
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发表时间：
1994-01-01
影响因子：
2.3
通讯作者：
FOLSOM, AR
中科院分区：
文献类型：
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作者：
BOSTICK, RM;POTTER, JD;FOLSOM, AR
为了研究蔗糖、肉类和脂肪的饮食摄入量，以及人体测量学、生活方式、激素和生殖因素与结肠癌发病率的关系，对35，215名爱荷华州（美国）年龄55-69岁、无癌症史的妇女进行了前瞻性队列研究，这些妇女于1986年完成了邮寄的饮食和其他问卷调查。到1990年，记录了212例结肠癌病例。比例风险回归用于校正年龄和其他风险因素。发现与结肠癌显著相关的风险因素包括：（i）除冰淇淋/牛奶外的含蔗糖食物和饮料;五分位数的相对风险（RR）= 1.00、1.73、1.56、1.54和2.00（五分位数2和5的95%置信区间[CI]不包括1.0）;（ii）蔗糖;五分位数的RR = 1.00、1.70、1.81、1.82和1.45（二至四个五分位数的置信区间不包括1.0）; ㈢身高;最高至最低五分位数的RR = 1.23（趋势P = 0.02）;（iv）体重指数; RR = 1.41（最高至最低五分位数）（趋势P = 0.03）;及（v）活产数目，与无活产相比，有一到两次活产的RR = 1.59，有三次或三次以上活产的RR = 1.80（趋势P = 0.04）。这些数据支持蔗糖摄入量或身高或肥胖增加结肠癌风险的假设;与增加产次降低风险的假设相反;支持以前的研究结果，即与年龄，吸烟或使用口服避孕药或雌激素替代疗法以外的人口统计学因素无关;并提出了关于以前与肉类，脂肪，蛋白质和体力活动相关的问题。
To investigate the relation of dietary intakes of sucrose, meat, and fat, and anthropometric, lifestyle, hormonal, and reproductive factors to colon cancer incidence, data were analyzed from a prospective cohort study of 35,215 Iowa (United States) women, aged 55-69 years and without a history of cancer, who completed mailed dietary and other questionnaires in 1986. Through 1990, 212 incident cases of colon cancer were documented. proportional hazards regression was used to adjust for age and other risk factors. Risk factors found to be associated significantly with colon cancer included: (i) sucrose-containing foods and beverages other than ice cream/milk; relative risks (RR) across the quintiles = 1.00, 1.73, 1.56, 1.54, and 2.00 (95% confidence intervals [CI] for quintiles two and five exclude 1.0);(ii) sucrose; RR across the quintiles = 1.00, 1.70, 1.81, 1.82, and 1.45 (CI for quintiles two through four exclude 1.0); (iii) height; RR = 1.23 for highest to lowest quintile (P for trend = 0.02); (iv) body mass index; RR = 1.41 for highest to lowest quintile(P for trend = 0.03); and (v) number of livebirths, RR = 1.59 for having had one to two livebirths and 1.80 for having had three or more livebirths compared with having had none (P for trend = 0.04). These data support hypotheses that sucrose intake or being tall or obese increases colon cancer risk; run contrary to the hypothesis that increased parity decreases risk; support previous findings of no association with demographic factors other than age, cigarette smoking, or use of oral contraceptives or estrogen replacement therapy; and raise questions regarding previous associations with meat, fat, protein, and physical activity.