Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study.
Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study.
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DOI：
10.22034/apjcp.2018.19.7.1911
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发表时间：
2018-07-27
期刊：
影响因子：
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通讯作者：
Nakamura K
中科院分区：
文献类型：
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作者：
Tsuchiya Y;Mishra K;Kapoor VK;Vishwakarma R;Behari A;Ikoma T;Asai T;Endoh K;Nakamura K
胆囊癌是印度北部妇女最常见的胃肠道癌症。一些研究调查了幽门螺杆菌感染与胆囊癌风险之间的关系，但研究结果并不一致。我们的目的是研究幽门螺杆菌感染与印度人胆囊癌之间的关系。我们进行了一项以医院为基础的病例对照研究，包括100名32至79岁胆囊癌合并胆结石患者（病例；72名女性，28名男性）和100名14至75岁胆石症患者（对照组；65名女性，35名男性）。2014年5月至2017年7月，在印度北部胆囊癌发病率高的勒克瑙桑杰甘地医学科学研究生院，所有患者都被诊断为胆囊癌或胆石症。所有患者术前均采集血浆标本。血浆幽门螺杆菌抗体滴度采用乳胶凝集法和自动分析仪测定。抗体滴度≥10 U/mL为幽门螺杆菌感染。比较两组患者血浆抗体滴度和幽门螺杆菌感染阳性率。患者平均血浆抗体滴度（标准差，范围）为11.1 U/mL(11.6, 0-78)，对照组为13.6 U/mL（23.0, 1-164）。病例组幽门螺杆菌感染阳性率为41%，对照组为42%。抗体滴度和幽门螺杆菌感染阳性率在病例和对照组之间无显著差异。我们没有发现证据表明幽门螺旋杆菌感染是印度人胆囊癌的重要危险因素。
Gallbladder cancer is the commonest gastrointestinal cancer in northern Indian women. Some studies have examined the association between Helicobacter pylori infection and gallbladder cancer risk, but findings have been inconsistent. We aimed to examine the association between H. pylori infection and gallbladder cancer in Indian people. We conducted a hospital-based case-control study including 100 gallbladder cancer patients with gallstones who were 32 to 79 years old (cases; 72 women and 28 men), and 100 cholelithiasis patients aged 14 to 75 years (controls; 65 women and 35 men). All patients had a diagnosis of gallbladder cancer or cholelithiasis at the Sanjay Gandhi Post Graduate Institute of Medical Sciences in Lucknow having a high gallbladder cancer incidence in northern India, from May 2014 through July 2017. Plasma samples were collected from all patients before surgical treatment. Plasma H. pylori antibody titer was measured by the latex agglutination method and an autoanalyzer. H. pylori infection was defined as antibody titer ≥10 U/mL. Plasma antibody titers and H. pylori infection positivity rates were compared between cases and controls. Mean plasma antibody titers (standard deviation, range) were 11.1 U/mL (11.6, 0–78) in cases and 13.6 U/mL (23.0, 1–164) in controls. H. pylori infection positivity rates were 41% and 42% in cases and controls, respectively. No significant differences in antibody titers or H. pylori infection positivity rates were found between cases and controls. We found no evidence of H. pylori infection as an important risk factor for gallbladder cancer in Indian people.