A pilot study of somatotopic mapping after cortical infarct
A pilot study of somatotopic mapping after cortical infarct
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DOI：
10.1161/01.str.31.3.668
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发表时间：
2000-03-01
期刊：
影响因子：
8.3
通讯作者：
Rosen, BR
中科院分区：
文献类型：
--
作者：
Cramer, SC;Moore, CI;Rosen, BR
背景和目的-动物研究描述了皮质梗塞后感觉和运动表征图的重塑。这些变化可能有助于中风后功能的恢复。方法-功能性 MRI 用于将 35 名正常对照受试者获得的感觉和运动图与 2 名皮质中风后 6 个月恢复良好的患者的结果进行比较。结果-在对照者的手指敲击过程中，42 例中的 40 例中央前回激活超过或匹配中央后回激活。 1 号患者有局限于中央前回的小梗塞。手指敲击仅激活中央后回，这种模式在任何对照受试者中都未见。在对对照组的手指或手进行触觉刺激时，有 14 例 II 例中央后回激活超过或匹配中央前回激活。 2 号患者有局限于中央后回和顶上小叶的小梗塞。手指的触觉刺激仅激活中央前回，这种模式在任何对照中都未见。在这两名患者中，胸肌收缩期间的激活位于手指敲击期间激活部位的内侧。结论 - 手指敲击（患者 1）和手指刺激（患者 2）期间的结果可能反映了正常感觉运动功能的保留部分的放大、手指表征的皮质部位的变化或两者兼而有之。沿梗塞边缘的皮质图重组可能是中风后运动和感觉功能恢复的重要贡献者。功能性 MRT 对于评估运动和感觉表征图很有用。
Background and Purpose-Animal studies have described remodeling of sensory and motor representational maps after cortical infarct. These changes may contribute to return of function after stroke.Methods-Functional MRI was used to compare sensory and motor maps obtained in 35 normal control subjects with results from 2 patients with good recovery 6 months after a cortical stroke.Results-During finger tapping in controls, precentral gyrus activation exceeded or matched postcentral gyrus activation in 40 of 42 cases. Patient 1 had a small infarct limited to precentral gyrus. Finger tapping activated only postcentral gyrus, a pattern not seen in any control subject. During tactile stimulation of a finger or hand in controls, postcentral gyrus activation exceeded or matched precentral gyrus activation in II of 14 cases. Patient 2 had a small infarct limited to postcentral gyrus and superior parietal lobule. Tactile stimulation of the finger activated only precentral gyrus, a pattern not seen in any control. In both patients, activation during pectoralis contraction was medial to the site activated during finger tapping.Conclusions-Results during finger tapping (patient 1) and finger stimulation (patient 2) may reflect amplification of a preserved component of normal sensorimotor function, a shift in the cortical site of finger representation or both. Cortical map reorganization along the infarct rim may be an important contributor to recovery of motor and sensory function after stroke. Functional MRT is useful for assessing motor and sensory representational maps.