Processing of proenkephalin is tissue-specific.
Processing of proenkephalin is tissue-specific.
复制标题
脑啡肽原的加工具有组织特异性。
DOI：
10.1126/science.6547780
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发表时间：
1984
期刊：
影响因子：
56.9
通讯作者：
J. Vanderhaeghen
中科院分区：
文献类型：
--
作者：
D. Liston;G. Patey;J. Rossier;P. Verbanck;J. Vanderhaeghen
大多数神经肽是作为大的前体蛋白质合成的。这些前体经历涉及产生生物活性肽的几个蛋白水解事件的成熟过程。这一过程的酶机制在很大程度上仍然是未知的。前体蛋白脑啡肽原的加工研究在两个不同的牛组织，下丘脑和肾上腺髓质。发现在这两种组织中积累的含脑啡肽的高分子量肽是不同的，表明这种神经肽前体存在两种加工途径。
Most neuropeptides are synthesized as large precursor proteins. These precursors undergo a maturation process involving several proteolytic events that generate the biologically active peptides. The enzymatic mechanisms underlying this processing are still largely unknown. The processing of the precursor protein proenkephalin was studied in two different bovine tissues, the hypothalamus and adrenal medulla. The high molecular weight enkephalin-containing peptides that accumulate in these two tissues were found to be different, indicating the existence of two processing pathways for this neuropeptide precursor.