Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children
Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children
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DOI：
10.1038/s41598-020-66729-9
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发表时间：
2020-06
影响因子：
4.6
通讯作者：
Kim Maasen;P. James;A. Prentice;S. Moore;C. Fall;G. Chandak;Modupeh Betts;M. Silver;J. Buxton
中科院分区：
文献类型：
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作者：
Kim Maasen;P. James;A. Prentice;S. Moore;C. Fall;G. Chandak;Modupeh Betts;M. Silver;J. Buxton
生命早期的暴露是成人疾病风险的重要预测因素。尽管根本机制尚不清楚，但可能涉及端粒维持。本研究调查了父母受孕时暴露的季节性差异与其后代白细胞端粒长度 (LTL) 之间的关系。 LTL 在两组 2 岁（N = 487）和 7-9 岁（N = 218）儿童队列中进行了测量。使用傅里叶回归模型检查受孕日期和 LTL 之间的关联，并根据年龄、性别、白细胞组成和其他潜在混杂因素进行调整。我们在所有模型中观察到季节对年龄较大的儿童的影响[似然比检验 (LRT) χ22= 7.1，p = 0.03；完全调整的模型]。 9 月（雨季）受孕的儿童 LTL 最大，3 月（旱季）受孕的儿童 LTL 最小，效应大小（LTL 峰值 - 最低点）为 0.60 z 分数。对于年幼的孩子来说，季节没有明显的影响（LRT χ2= 0.87，p = 0.65）。两个队列获得的不同结果可能反映了受孕季节对产后端粒维持的延迟影响。或者，它们也可以通过生命早期暴露的无法测量的差异或婴儿期端粒损耗率的增加来解释。
Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7–9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²2= 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak–nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²2= 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy.