RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline.
RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline.
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DOI：
10.1016/j.scr.2017.04.008
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发表时间：
2017-05
影响因子：
1.2
通讯作者：
Anderson RA
中科院分区：
文献类型：
--
作者：
Rosario R;Childs AJ;Anderson RA
原始生殖细胞在成为初级卵母细胞的过程中经历了三个重要的过程：减数分裂的开始，生殖细胞巢的形成和破裂，以及单个卵母细胞组装成原始卵泡。然而，在减数分裂开始时，生殖细胞在转录上变得沉默。因此，翻译控制预存储的mRNA在协调整个卵子发生的其余部分的基因表达中起着核心作用; RNA结合蛋白是这种调节的关键。在这篇综述中，我们研究了这些蛋白质的范例，即LIN 28，DAZL，BOLL和FMRP的作用，并强调它们在生殖细胞发育过程中的作用是至关重要的卵子发生和原始卵泡池的建立。RNA结合蛋白（RBP）是卵子发生过程中基因表达的关键调节因子。RBP LIN 28、DAZL、BOLL和FMRP在胎儿卵母细胞中显示阶段特异性表达。LIN 28和DAZL可能分别调节自我更新和进入减数分裂。BOLL和FMRP可能参与I期前期和卵母细胞生长的后期阶段。RBPs可能在胎儿期建立卵巢储备中起关键作用。
Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool. RNA-binding proteins (RBPs) are key regulators of gene expression during oogenesis. RBPs LIN28, DAZL, BOLL and FMRP display stage-specific expression in fetal oocytes. LIN28 and DAZL may regulate self-renewal and progression into meiosis respectively. BOLL and FMRP may be involved in the later stages of prophase I and oocyte growth. RBPs may have critical roles in establishing the ovarian reserve during fetal life.