Cognitive Functioning Prior to the Onset of Psychosis: The Role of Fetal Exposure to Serologically Determined Influenza Infection
Cognitive Functioning Prior to the Onset of Psychosis: The Role of Fetal Exposure to Serologically Determined Influenza Infection
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DOI：
10.1016/j.biopsych.2008.12.015
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发表时间：
2009-06-15
影响因子：
10.6
通讯作者：
Cannon, Tyrone D.
中科院分区：
文献类型：
--
作者：
Ellman, Lauren M.;Yolken, Robert H.;Cannon, Tyrone D.
工作背景：以前的研究已经将产前流感暴露与精神分裂症风险增加联系起来;然而，没有研究使用感染的血清学证据在精神病症状发作之前检查这种产前侮辱的神经发育后遗症。本研究旨在探讨产前流感A和B暴露的贡献，以认知能力的儿童谁开发的精神病在成年期与非精神病对照childhood.Methods：受试者为111例（70与精神分裂症和41与情感性精神病）和333匹配的对照受试者从妊娠期到7岁，通过围产期合作项目。使用韦氏儿童智力量表（7岁），通过病历审查评估成人精神病发病率，并通过验证研究证实。从出生时收集的存档产前母亲血清进行测定，并通过免疫球蛋白G（IgG）抗体滴度>第75百分位数来确定流感感染。言语智商和信息子测试显着下降，以及全量表智商分数和词汇量、理解力、数字广度的类似非显着下降，在产前暴露于B型流感的病例与未暴露于流感的病例之间发现了图片排列子测试。胎儿暴露于流感B并没有导致任何显着差异，在控制children.Conclusions：累积，这些研究结果表明，与精神病相关的遗传和/或环境因素使胎儿大脑特别容易受到流感13的影响，导致认知能力较差，甚至在症状发作之前。
Background: Previous studies have linked prenatal influenza exposure to increased risk of schizophrenia; however, no study has examined the neurodevelopmental sequelae of this prenatal insult before the onset of psychotic symptoms using serological evidence of infection. This study sought to examine the contribution of prenatal influenza A and B exposure to cognitive performance among children who developed psychoses in adulthood versus nonpsychiatric control children.Methods: Subjects were 111 cases (70 with schizophrenia and 41 with affective psychoses) and 333 matched control subjects followed from gestation until age 7 through the Collaborative Perinatal Project. The Wechsler Intelligence Scale for Children (age 7) was administered and adult psychiatric morbidity was assessed by medical records review and confirmed by a validation study. Assays were conducted from archived prenatal maternal sera collected at birth, and influenza infection was determined by immunoglobulin G (IgG) antibody titers >75th percentile.Results: Significant decreases in verbal IQ and the information subtest, as well as similar nonsignificant reductions in full scale IQ scores and vocabulary, comprehension, digit span, and picture arrangement subtests were found among cases who were prenatally exposed to influenza B versus cases who were not exposed. Fetal exposure to influenza B did not lead to any significant differences in cognitive performance among control children.Conclusions: Cumulatively, these findings suggest that a genetic and/or an environmental factor associated with psychosis rendered the fetal brain particularly vulnerable to the effects of influenza 13, leading to poorer cognitive performance even before symptom onset.