Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions
Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions
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DOI：
10.1016/j.ejpain.2006.02.002
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发表时间：
2007-04-01
影响因子：
3.6
通讯作者：
Rejas, Javier
中科院分区：
文献类型：
--
作者：
Galvez, Rafael;Marsal, Carlos;Rejas, Javier
目的：本横断面评估的目的是确定在标准护理条件下神经性疼痛（NeP）对患者功能和健康相关生活质量（HRQoL）的影响。参加DONEGA研究的NeP或神经性和伤害性疼痛[混合性疼痛（MP）]患者，DONEGA研究是一项在常规护理条件下观察加巴喷丁有效性的自然主义、前瞻性和多中心研究，在开始研究治疗前纳入本横断面评价。参与者完成了简短的麦吉尔疼痛问卷，MOS简短形式-12（SF-12）和希恩残疾量表（ShDS）。结果：共有1519例NeP或MP患者[平均值+/- SD; 56.0 +/- 13.7岁（58.8%为女性）]入选本研究。平均疼痛史为1.1 +/- 2.8年，5点视觉模拟量表上的当前疼痛强度为2.8 +/- 1.0，前一周的平均疼痛为71.3 +/- 19.0 mm。0-10量表评分>= 5），正常工作（5.9 +/- 3.0）、社会生活（5.7 +/- 3.0）和家庭生活（5.3 +/- 3.0），产生严重残疾（ShDS总分为16.9 +/- 8.3分）。SF-12的国家标准化身体（PC）和心理健康（MCS）组分总分表明，与一般西班牙人群相比，两个领域均存在显著损害：PC; -1.13 +/- 1.0 SDS（标准差评分）和MCS; -1.21 +/-0.7 SDS，分别相当于正常人群的第15和第25个年龄组。在标准护理条件下，神经性疼痛和混合性疼痛与身体和精神生活质量受损相关，在这些患者中产生相当程度的残疾。(c)2006年，国际疼痛研究协会欧洲分会联合会。由爱思唯尔有限公司出版。保留所有权利。
Aim: The purpose of this cross-sectional evaluation was to determine the impact of neuropathic pain (NeP) on patient functioning and Health-Related Quality of Life (HRQoL) under standard care conditions.Methods: Patients with NeP or neuropathic and nociceptive pain [Mixed Pain (MP)] enrolled in the DONEGA study, a naturalistic, prospective and multi-centre study of the effectiveness of gabapentin under usual care conditions, were included in this cross-sectional evaluation before starting study treatments. Participants completed the Short Form-McGill Pain Questionnaire, MOS Short Form-12 (SF-12), and Sheehan Disability Scale (ShDS). Multivariate analysis and regression models were used to analyze patient data.Results: A total of 1519 patients [mean +/- SD; 56.0 +/- 13.7 yrs old (58.8% female)] with NeP or MP were enrolled in the study. The mean pain history was 1.1 +/- 2.8 yrs, current pain intensity on a 5-point visual analogue scale was 2.8 +/- 1.0 and mean pain in previous week was 71.3 +/- 19.0 mm. Pain substantially interfered (i.e., score >= 5 on 0-10 scale) with normal work (5.9 +/- 3.0), social life (5.7 +/- 3.0), and family life (5.3 +/- 3.0), producing substantial disability (total ShDS score of 16.9 +/- 8.3 pts). Country-standardised physical (PCs) and mental health (MCS) component summary scores of SF-12 indicated significant impairment in both domains compared with the general Spanish population: PCs; -1.13 +/- 1.0 SDS (standard deviation score), and MCS; -1.21 +/- 0.7 SDS, equivalent to the 15th and 25th percentiles of normative populations, respectively.Conclusions: Under standard care conditions, neuropathic and mixed pain are associated with impaired physical and mental QoL, producing a substantial level of disability in these patients. (c) 2006 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.