CHEMICAL DISINFECTION OF CREUTZFELDT-JAKOB DISEASE VIRUS
CHEMICAL DISINFECTION OF CREUTZFELDT-JAKOB DISEASE VIRUS
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DOI：
10.1056/nejm198205273062107
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
GAJDUSEK, DC
中科院分区：
文献类型：
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作者：
BROWN, P;GIBBS, CJ;GAJDUSEK, DC
五年前在《期刊》上发表的关于对克雅氏病 (CJD) 患者受病毒污染的组织进行消毒的建议，1 很大程度上依赖于使用小鼠适应性痒病病毒进行的实验数据，当时该病毒是同一组海绵状脑病病毒中更方便研究的成员。我们现在已经积累了来自两名克雅氏病患者的豚鼠和小鼠适应性病毒分离株的足够数据，以便能够根据克雅氏病病毒本身的研究提出当前的建议。在至少 121°C (15 psi) 的温度下高压灭菌一小时仍然是灭菌的首选方法。 。 。
RECOMMENDATIONS for the disinfection of virus-contaminated tissues from patients with Creutzfeldt–Jakob disease (CJD), published five years ago in theJournal,1relied heavily on data from experiments using mouse-adapted scrapie virus — at that time a more conveniently studied member of the same group of spongiform encephalopathy viruses. We have now accumulated sufficient data on guinea-pig and mouse-adapted viral isolates from two patients with CJD to be able to present current recommendations based on studies of the CJD virus itself. Autoclaving for one hour at a temperature of at least 121°C (15 psi) remains the method of choice for the sterilization . . .