Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood
Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood
复制标题
DOI：
10.1016/j.envint.2020.106219
复制
发表时间：
2021-01-01
影响因子：
11.8
通讯作者：
Johannessen, Ane
中科院分区：
文献类型：
--
作者：
Kuiper, Ingrid Nordeide;Svanes, Cecilie;Johannessen, Ane
目的：调查从出生到成年期间的空气污染和绿色暴露是否会影响成人哮喘、鼻炎和肺功能。方法：我们分析了挪威和瑞典 RHINESSA 研究中 3428 名参与者（平均年龄 28 岁）的数据。对二氧化氮 (NO2)、颗粒物 (PM10 和 PM2.5)、黑碳 (BC)、臭氧 (O-3) 和绿化度（归一化植被指数 (NDVI)）的个人年均住宅暴露量在易感性窗口（0-10 岁、10-18 岁、一生、成年期（参与研究前一年））进行平均，并根据医生诊断的哮喘（曾经/过敏/非过敏）、最后一次哮喘发作进行分析12 个月，当前鼻炎和肺功能低下（正常下限 (LLN)、一秒用力呼气量 (FEV1) z 分数、用力肺活量 (FVC) 和 FEV1/FVC 低于 1.64）。我们对哮喘发作、鼻炎和 LLN 肺功能（以家庭和研究中心聚集）进行了逻辑回归，并对曾经/过敏/非过敏性哮喘进行了条件逻辑回归和匹配的病例对照设计。根据父母哮喘和教育程度调整多变量模型。结果：儿童期、青少年期和成人接触 NO2、PM10 和 O-3 与哮喘发作风险增加相关（OR 在 1.29 至 2.25 之间），但与医生诊断的哮喘无关。对于鼻炎，成年期接触似乎是最重要的。儿童期和青少年时期接触 PM2.5 和 O-3 与肺功能较低有关，尤其是 FEV1（范围 OR 2.65 至 4.21）。未发现 NDVI 与哮喘或鼻炎之间存在关联，但 NDVI 增加与所有易感性窗口中的 FEV1 和 FVC 降低相关（OR 范围为 1.39 至 1.74）。 结论：儿童期、青春期和成年期的空气污染暴露与成年期哮喘发作、鼻炎和肺功能低下的风险增加相关。绿色与哮喘或鼻炎无关，但却是肺功能低下的危险因素。
Objectives: To investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function.Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA study in Norway and Sweden. Individual mean annual residential exposures to nitrogen dioxide (NO2), particulate matter (PM10 and PM2.5), black carbon (BC), ozone (O-3) and greenness (normalized difference vegetation index (NDVI)) were averaged across susceptibility windows (0-10 years, 10-18 years, lifetime, adulthood (year before study participation)) and analysed in relation to physician diagnosed asthma (ever/allergic/non-allergic), asthma attack last 12 months, current rhinitis and low lung function (lower limit of normal (LLN), z-scores of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC below 1.64). We performed logistic regression for asthma attack, rhinitis and LLN lung function (clustered with family and study centre), and conditional logistic regression with a matched case-control design for ever/allergic/non-allergicasthma. Multivariable models were adjusted for parental asthma and education.Results: Childhood, adolescence and adult exposure to NO2, PM10 and O-3 were associated with an increased risk of asthma attacks (ORs between 1.29 and 2.25), but not with physician diagnosed asthma. For rhinitis, adulthood exposures seemed to be most important. Childhood and adolescence exposures to PM2.5 and O-3 were associated with lower lung function, in particular FEV1 (range ORs 2.65 to 4.21). No associations between NDVI and asthma or rhinitis were revealed, but increased NDVI was associated with lower FEV1 and FVC in all susceptibility windows (range ORs 1.39 to 1.74).Conclusions: Air pollution exposures in childhood, adolescence and adulthood were associated with increased risk of asthma attacks, rhinitis and low lung function in adulthood. Greenness was not associated with asthma or rhinitis, but was a risk factor for low lung function.