Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma.
Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma.
复制标题
补骨脂素加长波 UV-A (PUVA) 和贝沙罗汀疗法：一种有效且具有协同作用的联合辅助疗法，用于治疗晚期皮肤 T 细胞淋巴瘤患者。
DOI：
10.1001/archderm.139.6.771
复制
发表时间：
2003
影响因子：
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通讯作者：
J. Junkins
中科院分区：
文献类型：
--
作者：
K. McGinnis;M. Shapiro;C. Vittorio;A. Rook;J. Junkins
背景
多模式生物反应调节剂治疗，包括单采，干扰素和贝沙罗汀是标准的护理在我们的机构为晚期皮肤T细胞淋巴瘤与外周血受累。我们在5例Sézary综合征患者的治疗方案中加入了peptide+长波UV-A（PUVA）。
意见
所有患者在加入PUVA后均出现Sézary计数减少、淋巴结病消退和皮肤病清除。不良反应耐受良好，并通过密切的临床和实验室随访进行管理。
结论
在Sézary综合征患者的多模式免疫调节方案中添加PUVA可导致皮肤和血液传播疾病的快速和持续缓解。需要进一步的体外和体内研究。
BACKGROUND
Multimodality biological response-modifier therapy that includes photopheresis, interferon, and bexarotene is the standard of care in our institution for advanced cutaneous T-cell lymphoma with peripheral blood involvement. We added psoralen plus long-wave UV-A (PUVA) to this regimen in 5 patients with Sézary syndrome.
OBSERVATIONS
All patients responded with decreased Sézary counts, resolution of lymphadenopathy, and clearing of skin disease after the addition of PUVA. Adverse effects were well tolerated and managed via close clinical and laboratory follow-up.
CONCLUSIONS
The addition of PUVA to a multimodality immunomodulatory regimen in patients with Sézary syndrome can result in rapid and sustained remission of both skin and blood-borne disease. Further in vitro and in vivo studies are needed.
DOI：
--
发表时间：
2002-05
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Chunlei Zhang;P. Hazarika;X. Ni;D. Weidner;M. Duvic
通讯作者：
Chunlei Zhang;P. Hazarika;X. Ni;D. Weidner;M. Duvic
联合免疫调节疗法治疗皮肤 T 细胞淋巴瘤：单个机构 14 年的经验。
影响因子：
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作者：
Suchin,KarenRebecca;Cucchiara,AndrewJ;Gottleib,ScottL;Wolfe,JonathanT;DeNardo,BarbaraJ;Macey,WilliamH;Bromley,PatriciaG;Vittorio,CarmelaC;Rook,AlainH
通讯作者：
Rook,AlainH