Regulation of Trigeminal Respiratory Motor Activity in the Brainstem
Regulation of Trigeminal Respiratory Motor Activity in the Brainstem
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DOI：
10.1177/0022034509345998
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发表时间：
2009-11-01
影响因子：
7.6
通讯作者：
Kogo, M.
中科院分区：
文献类型：
--
作者：
Koizumi, H.;Nomura, K.;Kogo, M.
三叉神经运动系统参与控制呼吸以及吮吸和咀嚼。然而，三叉神经运动神经元呼吸活动的中枢机制还不清楚。在这项研究中，我们的目的是阐明体外新生大鼠脑干脊髓标本中三叉神经呼吸活动节律产生和信号传递的脑干回路。我们进一步研究了在三叉神经运动神经的呼吸和吸吮活动的双边同步的中线交叉三叉神经中间神经元的作用。脑干切片实验结果表明，呼吸节律在延髓产生，并传递到同侧的三叉神经运动神经元在脑桥。我们的结论是，三叉神经运动系统，以及舌下神经和膈神经运动系统，是由延髓呼吸网络，和脑桥之间的相互作用，双边三叉神经中间神经元的生成或同步的三叉神经呼吸活动是不重要的，但三叉神经吸吮活动是至关重要的。缩略语：GABA，γ-氨基丁酸; NMDA，N-甲基-D-天冬氨酸; pBC，前Botzinger复合体; V，三叉神经; XII，舌下神经。
The trigeminal motor system participates in the control of respiration as well as suckling and mastication. However, the central mechanism underlying respiratory activity in trigeminal motoneurons is not well-understood. In this study, we aimed to elucidate brainstem circuitry for rhythm generation and signal transmission of trigeminal respiratory activity in in vitro neonatal rat brainstem-spinal cord preparations. We further examined the role of midline-crossing trigeminal interneurons in the bilateral synchronization of respiratory and suckling activity in trigeminal motor nerves. The results of brainstem-sectioning experiments indicated that respiratory rhythms were generated in the medulla and ipsilaterally transmitted to trigeminal motoneurons in the pons. We conclude that the trigeminal motor system, as well as the hypoglossal and phrenic motor system, is regulated by medullary respiratory networks, and that pontine interactions between bilateral trigeminal interneurons are not critical for the generation or synchronization of trigeminal respiratory activity, but are crucial for trigeminal suckling activity. Abbreviations: GABA, gamma aminobutyric acid; NMDA, N-methyl-D-aspartic acid; pBC, pre-Botzinger complex; V, trigeminal; XII, hypoglossal.