The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?
The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?
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DOI：
10.1111/imr.12288
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发表时间：
2015-05
影响因子：
8.7
通讯作者：
Amer AO
中科院分区：
文献类型：
--
作者：
Abdelaziz DH;Khalil H;Cormet-Boyaka E;Amer AO
自噬最初被描述为负责维持细胞内营养稳态的主要分解代谢途径，涉及独特液泡、自噬体的形成以及与内体-溶酶体途径的相互作用。这种保守的机制在针对不同入侵者的免疫保护中发挥着关键作用，这些入侵者包括病原菌、细胞内寄生虫以及单纯疱疹和丙型肝炎病毒等一些病毒。重要的是，自噬与许多人类疾病和紊乱有关，包括神经退行性疾病、克罗恩病、II 型糖尿病、肿瘤发生、心肌病和脂肪肝疾病。另一方面，炎症小体是在多种环境条件和微生物感染下刺激的多蛋白平台。一旦组装，炎症小体就会介导促炎细胞因子的成熟，并促进吞噬体-溶酶体融合以维持先天免疫反应。在各种疾病和微生物感染中观察到自噬和炎症小体之间的交叉。这篇综述强调了不同医疗条件和微生物感染期间自噬和炎性小体相互作用所涉及的分子方面。
Autophagy is originally described as the main catabolic pathway responsible for maintaining intracellular nutritional homeosta-sis that involves the formation of a unique vacuole, the autophago-some, and the interaction with the endosome-lysosome pathways. This conserved machinery plays a key role in immune-protection against different invaders, including pathogenic bacteria, intracellular parasites, and some viruses like herpes simplex and hepatitis C virus. Importantly, autophagy is linked to a number of human diseases and disorders including neurodegenerative disease, Crohn’s disease, type II diabetes, tumorigenesis, cardiomyopathy, and fatty liver disease. On the other hand, inflammasomes are multiprotein platforms stimulated upon several environmental conditions and microbial infection. Once assembled, the inflammasomes mediate the maturation of pro-inflammatory cytokines and promote phagosome-lysosome fusion to sustain an innate immune response. The intersections between autophagy and inflammasome have been observed in various diseases and microbial infections. This review highlights the molecular aspects involved in autophagy and inflammasome interactions during different medical conditions and microbial infections.