Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry
Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry
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DOI：
10.1016/j.jaad.2005.07.046
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发表时间：
2005-12-01
影响因子：
13.8
通讯作者：
Marghoob, AA
中科院分区：
文献类型：
--
作者：
Agero, ALC;Benvenuto-Andrade, C;Marghoob, AA
背景：最近的回顾性研究使用磁共振成像（MRI）筛查神经系统无症状的儿童大先天性黑素细胞痣（LCMN）的神经性皮肤黑素细胞病（NCM）报告无症状NCM的高患病率（23%-30%）。我们试图确定无症状NCM的患病率，以及目前MRI作为筛查工具的应用。方法：来自互联网注册中心的LCMN患者回答了一份关于NCM状态的问卷。局限性：研究数据依赖于注册中心成员自我报告的发现，并且由于缺乏独立的数据验证而受到限制。结论：无症状NCM（由MRI确定）可能并不常见，其患病率（4.8%）远低于先前报道。MRI被广泛用于筛查有NCM风险的患者，如LCMN累及后轴和大于20个卫星痣的患者。
Background: Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23%-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool.Methods: Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.Limitations: Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.Conclusion: Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.