Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue
Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue
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DOI：
10.1016/j.bmcl.2006.07.027
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发表时间：
2006-10-01
影响因子：
2.7
通讯作者：
Komatsu, Yasuo
中科院分区：
文献类型：
--
作者：
Kojima, Naoshi;Sugino, Maiko;Komatsu, Yasuo
我们开发了一种新的氨基修饰试剂，其中一个氨基通过脂肪族连接器与芳香残基连接。结果表明，与传统的氨基修饰相比，芳香残基的插入可以提高氨基对寡核苷酸的反应性。(c) 2006 Elsevier Ltd.版权所有。
We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligo-nucleotides in comparison with conventional amino-modification. (c) 2006 Elsevier Ltd. All rights reserved.