Thalamocortical integration of instrumental learning and performance and their disintegration in addiction*
Thalamocortical integration of instrumental learning and performance and their disintegration in addiction*
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DOI：
10.1016/j.brainres.2014.12.023
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发表时间：
2015-12-02
期刊：
影响因子：
2.9
通讯作者：
Leung, Beatrice K.
中科院分区：
文献类型：
--
作者：
Balleine, Bernard W.;Morris, Richard W.;Leung, Beatrice K.
成瘾研究最近的一个焦点是药物暴露对神经过程的影响，这些神经过程介导目标导向工具行为的获得和表现。目标导向控制的缺陷和随之而来的习惯学习过程的失调被描述为导致强迫性药物寻求。同样，大量的研究集中在药物产生的动机和情绪变化上，这些变化导致了调节目标导向绩效的激励过程的变化。虽然这些领域是独立发展的，但我们认为它们所描述的影响可能不是独立的。在这里，我们假设，这些变化的结果从一个核心赤字的方式，支持目标导向的行动的学习和性能因素，在神经水平上整合，以保持行为控制。背侧基底神经节流介导的目标导向的学习和腹侧流介导的各种性能因素中找到几个整合点的皮质基底神经节系统，最显着的是在丘脑皮质网络连接基底神经节输出到各种皮质控制中心。最近在人类和其他动物的研究表明，学习和性能的因素被整合在一个网络为中心的mediodorsal丘脑和解体，在这个网络可能提供的基础上，从娱乐到失调的药物寻求导致有据可查的变化与addiction.This文章是一个特殊的问题，题为SI：成瘾电路的一部分。(C)2014爱思唯尔有限公司版权所有。
A recent focus of addiction research has been on the effect of drug exposure on the neural processes that mediate the acquisition and performance of goal-directed instrumental actions. Deficits in goal-directed control and a consequent dysregulation of habit learning processes have been described as resulting in compulsive drug seeking. Similarly, considerable research has focussed on the motivational and emotional changes that drugs produce and that result in changes in the incentive processes that modulate goal-directed performance. Although these areas have developed independently, we argue that the effects they described are likely not independent. Here we hypothesize that these changes result from a core deficit in the way the learning and performance factors that support goal-directed action are integrated at a neural level to maintain behavioural control. A dorsal basal ganglia stream mediating goal-directed learning and a ventral stream mediating various performance factors find several points of integration in the cortical basal ganglia system, most notably in the thalamocortical network linking basal ganglia output to a variety of cortical control centres. Recent research in humans and other animals is reviewed suggesting that learning and performance factors are integrated in a network centred on the mediodorsal thalamus and that disintegration in this network may provide the basis for a 'switch' from recreational to dysregulated drug seeking resulting in the well documented changes associated with addiction.This article is part of a Special Issue entitled SI:Addiction circuits. (C) 2014 Elsevier B.V. All rights reserved.