Mechanics and regulation of cytokinesis in budding yeast.
Mechanics and regulation of cytokinesis in budding yeast.
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DOI：
10.1016/j.semcdb.2016.12.010
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发表时间：
2017-06
影响因子：
7.3
通讯作者：
Bi E
中科院分区：
文献类型：
--
作者：
Bhavsar-Jog YP;Bi E
细胞分裂对于所有生物体的生存至关重要。它需要细胞信号传导、力产生、胞吐作用和细胞外基质重塑的协同功能。由于真菌和动物细胞之间核心成分和机制的保守性，芽殖酵母酿酒酵母已成为研究这一基本过程的有吸引力的模型。在这篇综述中，我们讨论了芽殖酵母胞质分裂的不同事件的机制和调节，包括肌动球蛋白环的组装、收缩和拆卸、隔膜的形成、脱落及其时空协调。我们还强调了动物和真菌胞质分裂常见的关键概念和问题。
Cytokinesis is essential for the survival of all organisms. It requires concerted functions of cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the conservation in core components and mechanisms between fungal and animal cells, the budding yeast Saccharomyces cerevisiae has served as an attractive model for studying this fundamental process. In this review, we discuss the mechanics and regulation of distinct events of cytokinesis in budding yeast, including the assembly, constriction, and disassembly of the actomyosin ring, septum formation, abscission, and their spatiotemporal coordination. We also highlight the key concepts and questions that are common to animal and fungal cytokinesis.