ANTI-LEUKEMIC EFFECT OF CHRONIC GRAFT VERSUS HOST-DISEASE - CONTRIBUTION TO IMPROVED SURVIVAL AFTER ALLOGENEIC MARROW TRANSPLANTATION
ANTI-LEUKEMIC EFFECT OF CHRONIC GRAFT VERSUS HOST-DISEASE - CONTRIBUTION TO IMPROVED SURVIVAL AFTER ALLOGENEIC MARROW TRANSPLANTATION
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DOI：
10.1056/nejm198106183042507
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发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
THOMAS, ED
中科院分区：
文献类型：
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作者：
WEIDEN, PL;SULLIVAN, KM;THOMAS, ED
异基因骨髓移植在急性白血病治疗中的使用频率越来越高。1234复发性白血病是急性非淋巴细胞白血病患者在疾病首次缓解时接受移植治疗失败的罕见原因，1，3，但复发是急性非淋巴细胞白血病或急性淋巴细胞白血病患者接受移植失败的主要原因。复发或第二次或随后的缓解。2，3，5试图降低白血病复发率与更有力的化学和放射治疗预处理方案通常是不成功的。2，6，7然而，我们以前报道，白血病复发率......
ALLOGENEIC marrow transplantation is being used with increasing frequency in the treatment of acute leukemia.1234Recurrent leukemia is an uncommon cause of therapeutic failure in patients with acute nonlymphoblastic leukemia who receive transplants while the disease is in first remission,1,3,4but recurrence is a major cause of failure in patients with acute nonlymphoblastic leukemia or acute lymphoblastic leukemia who receive transplants with the disease in relapse or in a second or subsequent remission.2,3,5Attempts to decrease the rate of leukemic relapse with more vigorous chemoradiotherapy conditioning regimens have generally been unsuccessful.2,6,7However, we previously reported that the rate of leukemic . . .