An update on lupus animal models.
An update on lupus animal models.
复制标题
DOI：
10.1097/bor.0000000000000412
复制
发表时间：
2017-09
影响因子：
5.1
通讯作者：
Morel L
中科院分区：
文献类型：
--
作者：
Li W;Titov AA;Morel L
系统性红斑狼疮（SLE）临床表现的复杂性和异质性，加上临床研究的固有局限性，使得很难直接在患者中调查这种疾病的病因。已经开发了各种小鼠模型来剖析SLE的细胞和遗传机制，以及鉴定治疗靶点和筛选治疗。本文综述了自发和诱导的SLE小鼠模型，并介绍了它们在该领域的最新进展。SLE的小鼠模型继续有助于理解导致疾病的细胞，信号传导和代谢机制，以及如何靶向这些途径可以提供治疗靶点。只要有可能，我们讨论了使用一个模型比其他的优势，以测试一个特定的假设自发和诱导模型的狼疮模型是有用的工具，研究疾病的病因，确定治疗靶点和筛选治疗的临床前研究。每个模型都与在人类中观察到的疾病共享特定的属性子集，这为研究人员提供了一种工具来适应他们的特定需求。
The complexity and heterogeneity of the clinical presentation in systemic lupus of erythematosus (SLE), combined to the inherent limitations of clinical research, have made it difficult to investigate the etiology of this disease directly in patients. Various mouse models have been developed to dissect the cellular and genetic mechanisms of SLE, as well as to identify therapeutic targets and to screen treatments. The purpose of this review is to summarize the major spontaneous and induced mouse models of SLE and to provide an update on the major advances they have contributed to the field. Mouse models of SLE have continued to contribute to understand the cellular, signaling and metabolic mechanisms contributing to the disease, and how targeting these pathways can provide therapeutic targets. Whenever possible, we discuss the advantage of using one model over the others to test a specific hypothesis Spontaneous and induced models of lupus models are useful tools for the study of the etiology of the disease, identify therapeutic targets and screen treatments in pre-clinical studies. Each model shares specific subsets of attributes with the disease observed in humans, which provides investigators a tool to tailor to their specific needs.