Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti‐interferon serum. VI. Polyoma virus infection
Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti‐interferon serum. VI. Polyoma virus infection
复制标题
使用抗多瘤病毒感染血清证明了干扰素在小鼠病毒性疾病发病机制中的作用。
DOI：
--
复制
发表时间：
1979
影响因子：
6.4
通讯作者：
M. Maunoury
中科院分区：
文献类型：
--
作者：
I. Gresser;C. Maury;C. Kress;D. Blangy;M. Maunoury
我们已经确定了单次注射强效羊抗小鼠干扰素球蛋白对瑞士小鼠多瘤病毒诱导的早期奔跑病和肿瘤形成的影响。当新生小鼠注射≥9 × 106 PFU的多瘤病毒时，16%（7/44）的小鼠死亡，而注射病毒和抗干扰素球蛋白的小鼠为96%（45/47）。同样，注射低剂量病毒和抗干扰素球蛋白的小鼠发生肿瘤的比例高于注射病毒的对照组小鼠。这些结果提示干扰素是决定新生小鼠对多瘤病毒易感性的一个重要因素。
We have determined the effect of a single injection of potent sheep anti‐mouse interferon globulin on polyoma‐virus‐induced early runting disease and tumor formation in Swiss mice. When newborn mice were injected with ≥9 × 106 PFU of polyoma virus, 16% (7/44) of mice runted and died in contrast to 96% (45/47) of mice injected with virus and anti‐interferon globulin. Likewise, a greater percentage of mice injected with lower doses of virus and anti‐interferon globulin developed tumors than did control virus‐injected mice. These results suggest that interferon is an important factor in determining the susceptibility of newborn mice to polyoma virus.