Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease
Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease
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DOI：
10.1097/01.wno.0000204645.56873.26
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Yüksel, N
中科院分区：
文献类型：
--
作者：
Iseri, PK;Altinas, Ö;Yüksel, N
背景：关于阿尔茨海默病（AD）是否伴随视网膜神经节细胞的丧失，目前存在相互矛盾的证据。为了评估这个问题，我们使用光学相干断层扫描（OCT）来评估视网膜的厚度和体积。我们还试图将我们的研究结果与视觉功能和认知defictions.Methods：我们评估了28眼14例AD患者和30眼15个年龄匹配的对照组。采用OCT测量两组视网膜神经纤维层（RNFL）厚度、黄斑厚度和黄斑体积，通过图形视觉诱发电位（VEP）信号潜伏期测量视功能，通过简易精神状态检查（MMSE）测量认知功能障碍。结果：AD患者各象限和位置的视乳头旁和黄斑RNFL厚度均薄于对照组。AD患者黄斑区平均总体积较对照组明显减小（P < 0.05）。黄斑总体积与MMSE评分显着相关。无显着差异被发现在潜伏期的视觉诱发电位P100的AD患者和对照subjects.Conclusions：我们的研究证实了其他一些研究表明，在AD患者有减少的视乳头旁和黄斑RNFL厚度和黄斑体积测量OCT。减少黄斑体积与认知功能障碍的严重程度。
Background: There is conflicting evidence as to whether Alzheimer disease (AD) is accompanied by loss of retinal ganglion cells. To evaluate this issue, we have used optical coherence tomography (OCT) to assess the thickness and volume of the retina. We have also sought to correlate our findings with visual function and cognitive impairment.Methods: We evaluated 28 eyes of 14 patients with AD and 30 eyes of 15 age-matched control subjects. In these two groups, we measured retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume with OCT, visual function through latency of the pattern visual evoked potential (VEP) signal, and cognitive impairment through the Mini-Mental State Examination (MMSE).Results: The parapapillary and macular RNFL thickness in all quadrants and positions of AD patients were thinner than in control subjects. The mean total macular volume of AD patients was significantly reduced as compared with control subjects (P < 0.05). Total macular volume and MMSE scores were significantly correlated. No significant difference was found in the latency of the VEP P100 of AD patients and control subjects.Conclusions: Our study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and macular volume as measured by OCT. The reduction in macular volume was related to the severity of cognitive impairment.