Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
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DOI：
10.1056/nejmoa2104882
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发表时间：
2021-06-03
期刊：
影响因子：
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通讯作者：
Holme PA
中科院分区：
文献类型：
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作者：
Schultz NH;Sørvoll IH;Michelsen AE;Munthe LA;Lund-Johansen F;Ahlen MT;Wiedmann M;Aamodt AH;Skattør TH;Tjønnfjord GE;Holme PA
我们报告了5名患者的发现，这些患者在接受第一剂ChAdOx 1 nCoV-19腺病毒载体疫苗后7至10天出现静脉血栓形成和血小板减少症，以对抗2019冠状病毒病（Covid-19）。患者为32至54岁的卫生保健工作者。所有患者都具有高水平的血小板因子4-聚阴离子复合物抗体;然而，他们之前没有接触过肝素。由于这5例病例发生在超过130，000名接种疫苗的人群中，我们认为它们代表了一种罕见的自发性肝素诱导血小板减少症的疫苗相关变体，我们称之为疫苗诱导的免疫血栓性血小板减少症。
We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4–polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.