Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes.
Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes.
复制标题
言语学习任务期间的代谢丘脑皮质相关性及其与区域体积之间的相关性的比较。
DOI：
10.1016/j.brainres.2006.07.043
复制
发表时间：
2006
期刊：
影响因子：
2.9
通讯作者：
Buchsbaum,MonteS
中科院分区：
文献类型：
--
作者：
Mitelman,SergeA;Byne,William;Kemether,EileenM;Newmark,RandallE;Hazlett,ErinA;Haznedar,MMehmet;Buchsbaum,MonteS
基于代谢和体积区域间相关性分析的方法已被用于神经影像学研究，但从未在同一组受试者中比较过相同感兴趣区域的代谢和体积区域间相关性。在59名健康受试者中获得磁共振和[18 F]-氟脱氧葡萄糖正电子发射断层扫描脑图像。在口头学习任务和相对灰质体积的相对葡萄糖代谢率的相关矩阵之间进行了编译手动追踪的mediodorsal，centromedial，和枕核的丘脑和39个皮质Brodmann的地区。皮质和这些丘脑核团之间的代谢相关性遵循非人类灵长类动物中已知的解剖连接模式。内背核的相互关系是广泛的前额叶皮层（9个，10个布罗德曼的区域在左半球）和颞叶（10个，11个布罗德曼的区域在左半球），而枕仅与顶叶和枕叶皮质区。不同的相关模式，观察区域灰质体积，只有枕产生广泛的皮质相互关联，主要是与枕，顶叶，前扣带，眶额区在右半球。代谢丘脑皮质相关性更广泛的mediodorsal和centromedian核，而结构相关性更广泛的枕。因此，代谢和体积相关性的方法是敏感的不同方面的区域间的关系在大脑和他们的比较在同一组的主题可能会呈现互补的，只有部分重叠的连接信息。
Methods based on the analysis of metabolic and volumetric interregional correlations have been used in neuroimaging research, yet metabolic and volumetric interregional correlations for identical regions of interest have never been compared in the same group of subjects. Magnetic resonance and [18F]-fluorodeoxyglucose positron emission tomography brain images were acquired in 59 healthy subject. Correlation matrices for relative glucose metabolic rates during a verbal learning task and for relative gray matter volumes were compiled between the manually traced mediodorsal, centromedian, and pulvinar nuclei of the thalamus and 39 cortical Brodmann's areas. Metabolic correlations between the cortex and these thalamic nuclei followed the known patterns of anatomical connectivity in non-human primates. Intercorrelations of the mediodorsal nucleus were widespread with the prefrontal cortex (9 out of 10 Brodmann's areas in the left hemisphere) and temporal lobe (10 out of 11 Brodmann's areas in the left hemisphere) while the pulvinar correlated only with the parietal and occipital cortical areas. Different correlation patterns were observed for the regional gray matter volumes whereby only the pulvinar yielded extensive cortical intercorrelations, primarily with the occipital, parietal, anterior cingulate, and orbitofrontal areas in the right hemisphere. Metabolic thalamocortical correlations were much more extensive for the mediodorsal and centromedian nuclei whereas structural correlations were more extensive for the pulvinar. Therefore, metabolic and volumetric correlational methods are sensitive to different aspects of interregional relations in the brain and their comparison in the same group of subjects may render complementary and only partially overlapping connectivity information.