Arachidonic Acid Metabolism in Cerebral Ischemia
Arachidonic Acid Metabolism in Cerebral Ischemia
复制标题
脑缺血时的花生四烯酸代谢
DOI：
10.1007/978-3-642-71787-1_29
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kenneth K. Wu
中科院分区：
文献类型：
--
作者：
L. Pettigrew;E. Hall;J. Grotta;Kenneth K. Wu
Cerebral ischemia and infarction result from impaired perfusion of brain tissue. Cellular homeostasis is disrupted by a variety of factors, one of which is deacylation of phospholipid membranes resulting in generation of arachidonic acid (AA) and its proaggregatory and vasoconstrictive metabolites, prostaglandin H2 (PGH2) and thromboxane A2 (TXA2). Our interest in AA metabolism in cerebral ischemia has developed from our studies of platelet-vessel wall interactions in the deendothelialized rabbit aorta. We have used this model, along with in vitro studies of platelet aggregation, to investigate pharmacological inhibition of AA metabolism. This paper will review our earlier work and give the results of experiments using 1-benzylimidazole (1-BI), a selective inhibitor of thromboxane synthase, in a rat model of transient forebrain ischemia.
13-氮杂前列腺素酸对血栓素 A2/前列腺素 H2 的拮抗作用可防止体内血小板沉积到去内皮化的兔主动脉。
DOI：
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发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
LeBreton,GC;Lipowski,JP;Feinberg,H;Venton,DL;Ho,T;Wu,KK
通讯作者：
Wu,KK
血小板血栓素 A2 的产生会使纯化的人血小板血栓素合酶失活。
DOI：
10.1042/bj2330637
发表时间：
1986
期刊：
The Biochemical journal
影响因子：
--
作者：
Hall,ER;Tuan,WM;Venton,DL
通讯作者：
Venton,DL