Surface Plasmon-Coupled Emission: What Can Directional Fluorescence Bring to the Analytical Sciences?
Surface Plasmon-Coupled Emission: What Can Directional Fluorescence Bring to the Analytical Sciences?
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DOI：
10.1146/annurev-anchem-062011-143208
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Li, Yao-Qun
中科院分区：
文献类型：
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作者：
Cao, Shuo-Hui;Cai, Wei-Peng;Li, Yao-Qun
表面等离子体激元耦合发射（SPCE）是荧光和等离子体激元两个迅速发展的研究领域的结合。SPCE揭示了新的现象，并在生物分析，医学诊断，药物发现和基因组学中具有潜在的应用。在SPCE中，激发的荧光团与连续薄金属膜上的表面等离子体耦合;等离子体团辐射到具有窄角分布的高折射率介质中。由于定向发射，该技术的灵敏度可以大大提高，具有高收集效率。本文介绍了SPCE的独特功能。特别是，我们专注于SPCE为基础的分析平台及其在DNA传感和其他生物分子和化学品的检测应用的最新进展。
Surface plasmon-coupled emission (SPCE) arose from the integration of fluorescence and plasmonics, two rapidly expanding research fields. SPCE is revealing novel phenomena and has potential applications in bioanalysis, medical diagnostics, drug discovery, and genomics. In SPCE, excited fluorophores couple with surface plasmons on a continuous thin metal film; plasmophores radiate into a higher-refractive index medium with a narrow angular distribution. Because of the directional emission, the sensitivity of this technique can be greatly improved with high collection efficiency. This review describes the unique features of SPCE. In particular, we focus on recent advances in SPCE-based analytical platforms and their applications in DNA sensing and the detection of other biomolecules and chemicals.