Postprandial lipid responses to standard carbohydrates used to determine glycaemic index values.
Postprandial lipid responses to standard carbohydrates used to determine glycaemic index values.
复制标题
餐后脂质对用于确定血糖指数值的标准碳水化合物的反应。
DOI：
10.1017/s000711451300130x
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发表时间：
2013-11
影响因子：
3.6
通讯作者：
Lichtenstein, Alice H.
中科院分区：
文献类型：
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作者：
Vega-Lopez, Sonia;Ausman, Lynne M.;Matthan, Nirupa R.;Lichtenstein, Alice H.
以前评估不同类型碳水化合物的代谢影响的研究都集中在它们的血糖反应上。然而，这些研究没有考虑餐后心脏代谢风险指标的反应。本研究在受控条件下，通过个体内重复测定，评估了两种形式的碳水化合物对餐后血脂的反应，这两种碳水化合物被用作血糖指数测定的参考食物，白面包(50克可用碳水化合物)和葡萄糖(50克)。共有20名成年人(20-70岁)经历了两个周期的挑战，每对参考食物(四个挑战/人)，在标准条件下的不同日期随机给予。服药后5h监测血脂(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和NEFA)、血糖和胰岛素。口服葡萄糖导致的血糖和胰岛素反应在前90min比白面包更大，120min后下降更大(P=0.0001)。口服葡萄糖后血清NEFA浓度的初始下降幅度大于白面包攻击后，150min后的反弹(P=0.001)。然而，碳水化合物的类型对餐后总胆固醇、低密度脂蛋白-胆固醇和高密度脂蛋白-胆固醇浓度没有显著影响。在对这两个挑战做出反应后，TAG浓度最初略有上升，但在接受白面包挑战时，这些值降至低于空腹血糖值的水平。这些数据表明，用于确定血糖指数的碳水化合物类型，面包或葡萄糖，对餐后血浆胆固醇浓度影响很小或不大。TAG和NEFA在5小时内的浓度差异不大，它们的临床相关性尚不清楚。
Prior studies assessing the metabolic effects of different types of carbohydrates have focused on their glycaemic response. However, the response of postprandial cardiometabolic risk indicators has not been considered in these studies. The present study assessed postprandial lipid responses to two forms of carbohydrates used as reference foods for glycaemic index determinations, white bread (50 g available carbohydrate) and glucose (50 g), under controlled conditions and with intra-individual replicate determinations. A total of twenty adults (20–70 years) underwent two cycles of challenges with each pair of reference foods (four challenges/person), administered in a random order on separate days under standard conditions. Serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG and NEFA), glucose and insulin were monitored for 5 h post-ingestion. Oral glucose resulted in greater glycaemic and insulinaemic responses than white bread for the first 90 min and a greater subsequent decline after 120 min (P = 0.0001). The initial decline in serum NEFA concentrations was greater after the oral glucose than after the white bread challenge, as was the rebound after 150 min (P = 0.001). Nevertheless, the type of carbohydrate had no significant effect on postprandial total cholesterol, LDL-cholesterol and HDL-cholesterol concentrations. Following an initial modest rise in TAG concentrations in response to both challenges, the values dropped below the fasting values for oral glucose but not for the white bread challenge. These data suggest that the type of carbohydrate used to determine the glycaemic index, bread or glucose, has little or modest effects on postprandial plasma cholesterol concentrations. Differences in TAG and NEFA concentrations over the 5 h time period were modest, and their clinical relevance is unclear.