Intrathecal baclofen in current neuromodulatory practice: established indications and emerging applications.
Intrathecal baclofen in current neuromodulatory practice: established indications and emerging applications.
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当前神经调节实践中鞘内注射巴氯芬：既定适应症和新兴应用。
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
D. Sakas
中科院分区：
文献类型：
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作者：
I. Panourias;M. Themistocleous;D. Sakas
鞘内注射巴氯芬 (ITB) 已发展成为治疗脊柱和脑源性严重痉挛的标准疗法。从接受 ITB 治疗的一系列患者的报告中积累的有希望的数据，以及痉挛性张力亢进通常与其他神经系统疾病共存的事实，为向患有其他运动障碍的患者提供此类治疗奠定了坚实的基础。这些包括运动障碍，如肌张力障碍、肌萎缩侧索硬化症、肌张力障碍、Hallervorden-Spatz 病、弗赖德赖希共济失调、“僵人”综合征，还包括脑外伤、缺氧性脑病或其他病理后的植物人状态，以及最近的各种慢性疼痛综合征。在本文中，基于 ITB 疗法的既定应用，我们回顾了这种有益的神经调节方法的重要新兴适应症，并试图确定其未来在其他慢性和难治性神经系统疾病中的潜在有益作用。
Intrathecal baclofen (ITB) has evolved into a standard treatment for severe spasticity of both spinal and cerebral origin. The accumulated promising data from reported series of patients receiving ITB therapy together with the fact that spastic hypertonia commonly coexists with other neurological disorders have constituted a solid basis for offering this kind of treatment to patients suffering from other movement disorders. These include motor disorders such as dystonia, amyotrophic lateral sclerosis, status dystonicus, Hallervorden-Spatz disease, Freidreich's ataxia, "stiff-man" syndrome, but also vegetative states after revere brain trauma, anoxic encephalopathy or other pathology and more recently, various chronic pain syndromes. In this article, on the basis of the established applications of ITB therapy, we review the important emerging indications of this rewarding neuromodulation method and attempt to identify its future potential beneficial role in other chronic and otherwise refractory neurological disorders.
分泌神经末梢中 GABA 激活的氯离子通道。
DOI：
10.1126/science.8380942
发表时间：
1993
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zhang,SJ;Jackson,MB
通讯作者：
Jackson,MB
鞘内注射巴氯芬对痉挛患者功能的影响。
影响因子：
3.2
作者：
Campbell,SK;Almeida,GL;Penn,RD;Corcos,DM
通讯作者：
Corcos,DM