An Outbreak of Ebola Virus Disease in the Lassa Fever Zone
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone
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DOI：
10.1093/infdis/jiw239
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发表时间：
2016-10-15
影响因子：
6.4
通讯作者：
Garry, Robert F.
中科院分区：
文献类型：
--
作者：
Goba, Augustine;Khan, S. Humarr;Garry, Robert F.
背景。凯内马政府医院 (KGH) 已发展出先进的临床和实验室研究能力来应对拉沙热（一种病毒性出血热 (VHF)）的威胁。 2013-2016 年埃博拉病毒 (EBOV) 疾病 (EVD) 疫情首次发生在靠近已建立 VHF 研究临床和实验室能力的设施的地区。Methods.aEuro积分 由于靠近 2014 年 3 月在几内亚爆发的 EVD 疫情中心，KGH 拉沙热小组动员起来建立 EBOV 监测和诊断 2014 年 5 月 25 日，KGH 拉沙病毒实验室主任、欧洲积分奥古斯丁·戈巴 (Augustine Goba) 诊断出塞拉利昂首例有记录的埃博拉病毒病病例。此后，KGH 接收和护理的埃博拉病毒病患者数量迅速超出了安全管理的能力。许多医护人员感染埃博拉病毒病并丧生。西非随后发生的绝大多数埃博拉病毒病病例都可以追溯到包括首例确诊病例在内的单一传播链。 结论.a 欧元积分 应对两种出血热病毒的挑战将需要持续投资于开发对策（疫苗、治疗药物和诊断检测）、基础设施和人力资源。
Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013- 2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs.Methods.aEuro integral Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities.Results.aEuro integral Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case.Conclusions.aEuro integral Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.