When the same response has different meanings: recoding the response meaning in the lateral prefrontal cortex
When the same response has different meanings: recoding the response meaning in the lateral prefrontal cortex
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DOI：
10.1016/s1053-8119(03)00357-4
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发表时间：
2003-10-01
期刊：
影响因子：
5.7
通讯作者：
von Cramon, DY
中科院分区：
文献类型：
--
作者：
Brass, M;Ruge, H;von Cramon, DY
使我们的行为库适应不同情况和任务的能力对我们的行为控制至关重要。由于相同的运动行为在不同的任务情境中可能有不同的含义，因此当我们进入不同的任务情境时，我们往往不得不改变我们反应的含义。在一个功能性磁共振成像实验中，我们操纵了这个反应重新编码过程。被试被要求在任务转换范式中执行两个简单的空间任务。在一个条件下，两个任务都需要相同的一组响应，因此每个响应都有两个不同的含义取决于相关的任务（二价条件）。在其他条件下，受试者对每个任务使用一套单独的反应（单价条件）。虽然受试者被要求重新编码的意义时，从一个任务切换到下一个在二价条件下，响应重新编码是不需要在单价条件。我们证明，外侧前额叶皮层参与反应意义的重新编码。这些结果扩展了先前关于前额叶皮层在行为控制中的作用的假设。(C)2003年爱思唯尔公司All rights reserved.
The ability to adapt our behavioral repertoire to different situations and tasks is crucial for our behavioral control. Since the same motor behavior can have different meanings in different task situations, we often have to change the meaning of our responses when we get into a different task context. In a functional MRI experiment we manipulated this response recoding process. Subjects were required to execute two simple spatial tasks in a task switching paradigm. In one condition both tasks required the same set of responses, hence each response had two different meanings depending on the relevant task (bivalent condition). In the other condition subjects used a separate set of responses for each task (univalent condition). While subjects were required to recode the meaning when switching from one task to the next in the bivalent condition, response recoding was not required in the univalent condition. We demonstrate that the lateral prefrontal cortex is involved in recoding of response meaning. These results extend previous assumptions on the role of the prefrontal cortex in behavioral control. (C) 2003 Elsevier Inc. All rights reserved.