Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system
Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system
复制标题
DOI：
10.1016/j.ejphar.2013.11.033
复制
发表时间：
2014-01-15
影响因子：
5
通讯作者：
Shoferpour, Mehdi
中科院分区：
文献类型：
--
作者：
Banafshe, Hamid R.;Hamidi, Gholam A.;Shoferpour, Mehdi
神经病理性疼痛是糖尿病最常见的并发症之一。由于目前神经病理性疼痛的治疗效果和耐受性并不理想，我们需要开发新的药物以更好地治疗。姜黄素是姜黄中的一种天然黄酮类化合物，具有抗抑郁、抗伤害和神经保护等作用。本研究旨在探讨姜黄素对糖尿病周围神经病理性疼痛的影响及阿片系统的可能参与。腹腔注射链脲佐菌素60 mg/kg诱导大鼠糖尿病模型。用姜黄素（50 mg/kg/d）对STZ诱导的糖尿病大鼠进行急性和慢性治疗。在糖尿病诱导后0、7、14和21天测量热痛觉过敏和机械异常性疼痛作为神经病理性疼痛的行为评分。姜黄素的慢性而非急性治疗可防止STZ诱导的糖尿病大鼠的体重减轻并减弱机械性异常性疼痛。在von Frey细丝试验中，纳洛酮（1 mg/kg）预处理显著降低慢性姜黄素的抗异常性疼痛作用。我们的研究结果表明，姜黄素可以被认为是一种新的治疗糖尿病神经病理性疼痛的治疗潜力和阿片系统的激活可能参与姜黄素的抗伤害性感受作用。(C)2013 Elsevier B. V.保留所有权利，
Neuropathic pain is one of the most common complications of diabetes mellitus. As efficacy and tolerability of current therapy for neuropathic pain are not ideal, we need to develop the novel drug for better treatment. Curcumin as a natural flavonoid from Curcuma Longa has considerable effects on nervous system such as, antidepressant, antinociceptive and neuroprotective effects. The present study was designed to investigate the effect of curcumin on diabetic peripheral neuropathic pain and possible involvement of opioid system. A single close of 60 mg/kg streptozotocin was injected intraperitoneally to induce diabetes in rats. STZ-induced diabetic rats were treated with curcumin (50 mg/kg/day) acute and chronically. Thermal hyperalgesia and mechanical allodynia were measured on the days 0, 7, 14 and 21 after diabetes induction as behavioral scores of neuropathic pain. Chronic, but not acute, treatment with curcumin prevents the weight loss and attenuates mechanical allodynia in STZ-induced diabetic rats. Pretreatment with naloxone (1 mg/kg) significantly reduced anti-allodynic effect of chronic curcumin in von Frey filament test. Our results suggest that curcumin can be considered as a new therapeutic potential for the treatment of diabetic neuropathic pain and the activation of opioid system may be involved in the antinociceptive effect of curcumin. (C) 2013 Elsevier B.V. All rights reserved,