The indoor air and asthma: the role of cat allergens.
The indoor air and asthma: the role of cat allergens.
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DOI：
10.1097/mcp.0b013e32834db10d
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发表时间：
2012-01
影响因子：
3.3
通讯作者：
Platts-Mills TA
中科院分区：
文献类型：
--
作者：
Kelly LA;Erwin EA;Platts-Mills TA
目的是讨论我们对室内环境在哮喘中的作用的了解的最新进展，重点是猫过敏原的特殊作用。对Fel d 1的致敏是对猫的吸入反应中的主要事件;然而，也存在对脂质运载蛋白（Fel d 4）、猫白蛋白（Fel d 2）和猫伊加（Fel d 5 w）和其他分子上的寡糖半乳糖-α-1，3-半乳糖（α-gal）的IgE反应。现在认为这些过敏原的剂量反应和致敏途径是多种多样的。重要的是要记住，在有猫的房子外面暴露足以引起过敏。此外，关于在哮喘中的作用的唯一可靠证据涉及Fel d 1。最近，研究表明，与早期接触猫相关的耐受性可以持续到18岁，并且对α-gal（猫伊加）的IgE与哮喘无关。此外，最近一项关于抗IgE的研究进一步证实，室内过敏原的IgE抗体对哮喘的严重程度有重要影响。在有猫的家中暴露于Fel d 1远高于诱导过敏（IgE抗体）反应所需的水平。与此相一致，儿童可能会发展出长期的耐受性。此外，越来越多的证据表明，吸入性过敏原（如Fel d 1、尘螨或蟑螂）的IgE抗体与肺部炎症和哮喘有因果关系。
The objective is to discuss recent progress in our understanding of the role of the indoor environment in asthma, focusing on the special role of cat allergens. Sensitization to Fel d 1 is the dominant event in inhalant responses to cat; however, there are also IgE responses to the lipocalin (Fel d 4), to cat albumin (Fel d 2), and to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) on cat IgA (Fel d 5w) and other molecules. The dose response and routes of sensitization for these allergens are now thought to be diverse. It is important to remember that exposure outside a house with a cat is sufficient to cause sensitization. Furthermore, the only solid evidence about a role in asthma relates to Fel d 1. Recently, it has been shown that tolerance associated with early exposure to cats can persist to age 18 and that IgE to alpha-gal (on cat IgA) is not related to asthma. In addition, a recent study of anti-IgE reinforces the evidence that IgE antibodies to indoor allergens make a major contribution to asthma severity. Exposure to Fel d 1 in a home with a cat is far higher than the levels necessary to induce an allergic (IgE antibody) response. In keeping with that, children may develop tolerance, which can be long-lived. In addition, there is increasing evidence that IgE antibodies to an inhalant allergen, such as Fel d 1, dust mite, or cockroach, are causally related to lung inflammation and asthma.