Accuracy of free-breathing multi-parametric SASHA in identifying T1 and T2 elevations in pediatric orthotopic heart transplant patients.
Accuracy of free-breathing multi-parametric SASHA in identifying T1 and T2 elevations in pediatric orthotopic heart transplant patients.
复制标题
自由呼吸多参数 SASHA 在识别儿科原位心脏移植患者 T1 和 T2 升高方面的准确性。
DOI：
10.1007/s10554-023-02965-0
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Olivieri,Laura
中科院分区：
文献类型：
--
作者：
Richmann,DevikaP;Contento,Jacqueline;Cleveland,Vincent;Hamman,Karin;Downing,Tacy;Kanter,Joshua;Berger3rd,JohnT;Christopher,Adam;Cross,Russell;Chow,Kelvin;Olivieri,Laura
T1/T2参数标测可以揭示心肌疾病中的升高模式（“热点”），例如原位心脏移植（OHT）患者的排斥反应。本研究旨在评价自由呼吸（FB）多参数饱和恢复单次采集（mSASHA）T1/T2标测在识别儿科OHT患者常规屏气改良Look-Perth反转恢复（BH MOLLI）T1和T2准备平衡稳态自由进动（BH T2 p-bSSFP）标测图上存在的热点方面的诊断准确性。儿科OHT患者在8个短轴切片中使用BH MOLLI T1和T2 p-bSSFP以及原型FB mSASHA T1/T2标测进行了非造影剂1.5T CMR。使用半自动阈值化（ITK-SNAP）分割FB和BH T1/T2热点，并收集它们的3D坐标位置（3-Matic，Materialise，Leuven，Belgium）。采用受试者工作特征曲线分析和集中趋势测量。获得了23名儿童OHT患者的40个成像数据集。与标准BH MOLLI相比，FB mSASHA对T1和T2标测图的灵敏度分别为82.8%和80%，对T1和T2标测图的特异性均为100%。当在FB和BH标测图上识别时，所有情况下的热点都重叠，T1标测图上FB和BH热点中心之间的平均长轴偏移为5.8 mm（IQR 3.5-8.2），T2标测图上为5.9 mm（IQR 3.5-8.2）。FB mSASHA T1/T2标测图可以识别OHT儿科患者常规BH T1/T2标测图上存在的热点，具有高灵敏度、特异性和3D空间重叠。自由呼吸标测可改善患者舒适度，并有助于年轻患者人群的OHT评估。
T1/T2 parametric mapping may reveal patterns of elevation (“hotspots”) in myocardial diseases, such as rejection in orthotopic heart transplant (OHT) patients. This study aimed to evaluate the diagnostic accuracy of free-breathing (FB) multi-parametric SAturation recovery single-SHot Acquisition (mSASHA) T1/T2 mapping in identifying hotspots present on conventional Breath-held Modified Look-Locker Inversion recovery (BH MOLLI) T1 and T2-prepared balanced steady-state free-precession (BH T2p-bSSFP) maps in pediatric OHT patients. Pediatric OHT patients underwent noncontrast 1.5T CMR with BH MOLLI T1 and T2p-bSSFP and prototype FB mSASHA T1/T2 mapping in 8 short-axis slices. FB and BH T1/T2 hotspots were segmented using semi-automated thresholding (ITK-SNAP) and their 3D coordinate locations were collected (3-Matic, Materialise, Leuven, Belgium). Receiver operator characteristic curve analysis and measures of central tendency were utilized. 40 imaging datasets from 23 pediatric OHT patients were obtained. FB mSASHA yielded a sensitivity of 82.8% for T1 and 80% for T2 maps when compared to the standard BH MOLLI, as well as 100% specificity for both T1 and T2 maps. When identified on both FB and BH maps, hotspots overlapped in all cases, with an average long axis offset between FB and BH hotspot centers of 5.8 mm (IQR 3.5–8.2) on T1 and 5.9 mm (IQR 3.5–8.2) on T2 maps. FB mSASHA T1/T2 maps can identify hotspots present on conventional BH T1/T2 maps in pediatric patients with OHT, with high sensitivity, specificity, and overlap in 3D space. Free-breathing mapping may improve patient comfort and facilitate OHT assessment in younger patient populations.