Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model
Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model
复制标题
在4T1小鼠乳腺癌转移模型中，低局部血液灌注、高白细胞和高血小板计数与原发肿瘤生长和肺转移相关
DOI：
10.3892/ol.2015.3304
复制
发表时间：
2015-08-01
期刊：
影响因子：
2.9
通讯作者：
Chen, Su-Hong
中科院分区：
文献类型：
--
作者：
Wang, Chuan;Chen, Ying-Ge;Chen, Su-Hong
最初人们认为，没有一项常规血液测试结果能够表明患者是否患有癌症；然而，几项新的研究表明，癌症患者的中位生存期和预后与癌症患者的全身循环特征显著相关。此外，某些参数，如白细胞(WBC)计数，在恶性肿瘤中也发生了很大程度的改变。本研究通过常规血常规检查，观察荷瘤小鼠乳腺脂肪垫内植入411乳腺癌细胞后血细胞的变化，并用激光多普勒血流成像(LDPI)间接测量肿瘤部位的血流量，试图解释血液循环特征与乳腺癌生长转移的相关性。LDPI和血液检测结果表明，BALB小鼠体内接种411乳腺癌细胞后出现血栓形成，并出现高白细胞数、高血小板数、高血小板压积和低血流灌注量。41‘1细胞接种4周后，测定肺转移灶数目，皮尔逊相关系数显示脏器肺转移灶数目与嗜碱性粒细胞比率呈显著负相关(BAS0%；r=-0.512；P
It was originally thought that no single routine blood test result would be able to indicate whether or not a patient had cancer; however, several novel studies have indicated that the median survival and prognosis of cancer patients were markedly associated with the systemic circulation features of cancer patients. In addition, certain parameters, such as white blood cell (WBC) count, were largely altered in malignant tumors. In the present study, routine blood tests were performed in order to observe the change of blood cells in tumor-bearing mice following the implantation of 411 breast cancer cells into the mammary fat pad; in addition, blood flow in breast tumor sites was measured indirectly using laser Doppler perfusion imaging (LDPI), in an attempt to explain the relevance between the blood circulation features and the growth or metastasis of breast cancer in mice model. The LDPI and blood test results indicated that the implantation of 411 breast cancer cells into BALBic mice led to thrombosis as well as high WBC count, high platelet count, high plateletcrit and low blood perfusion. Following implantation of the 41'1 cells for four weeks, the lung metastatic number was determined and the Pearson correlation coefficient revealed that the number of visceral lung metastatic sites had a marked negative association with the ratio of basophils (BAS0%; r=-0.512; P