The ERK MAP kinase cascade mediates tail swelling and a to rectal infection protective response in C-elegans
The ERK MAP kinase cascade mediates tail swelling and a to rectal infection protective response in C-elegans
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DOI：
10.1016/j.cub.2004.07.022
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发表时间：
2004-07-27
期刊：
影响因子：
9.2
通讯作者：
Hodgkin, J
中科院分区：
文献类型：
--
作者：
Nicholas, HR;Hodgkin, J
线虫秀丽隐杆线虫被证明是一种有吸引力的模式生物，用于研究对感染的先天免疫应答[1]。在已知的C.线虫的病原体是嗜热微杆菌（Microbacteriumophilum），其粘附于线虫的直肠和肛后角质层，引起下面的皮下组织肿胀并引起轻度便秘[2]。我们发现感染M.嗜酸乳杆菌是一种细胞外信号调节激酶（ERK）丝裂原活化蛋白（MAP）激酶级联反应，介导尾肿胀并保护C.严重的便秘，否则会阻碍发展，导致不育。参与病原体防御代表了ERK MAP激酶信号转导在这种生物体中的新作用。
The nematode Caenorhabditis elegans is proving to be an attractive model organism for investigating innate immune responses to infection [1]. Among the known pathogens of C. elegans is the bacterium Microbacterium nematophilum, which adheres to the nematode rectum and postanal cuticle, inducing swelling of the underlying hypodermal tissue and causing mild constipation [2]. We find that on infection by M. nematophilum, an extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase cascade mediates tail swelling and protects C. elegans from severe constipation, which would otherwise arrest development and cause sterility. Involvement in pathogen defense represents a new role for ERK MAP kinase signaling in this organism.