Protective effect of green tea on the risks of chronic gastritis and stomach cancer
Protective effect of green tea on the risks of chronic gastritis and stomach cancer
复制标题
DOI：
10.1002/ijc.1231
复制
发表时间：
2001-05-15
影响因子：
6.4
通讯作者：
Hsieh, CC
中科院分区：
文献类型：
--
作者：
Setiawan, VW;Zhang, ZF;Hsieh, CC
尽管发病率呈下降趋势，但胃癌仍是全球第二大常见癌症。我们研究了饮用绿茶对慢性胃炎和胃癌风险的影响。在中国扬中市进行了一项基于人群的病例对照研究，其中133例胃癌病例，166例慢性胃炎病例，433例健康对照。采用标准问卷收集流行病学资料，采用SAS中的logistic回归模型估计比值比（OR）和95%置信区间（CI）。绿茶饮用与慢性胃炎和胃癌风险呈负相关。在调整了年龄、性别、受教育程度、体重指数、吸烟和饮酒的包年后，饮用绿茶对胃癌和慢性胃炎的or分别为0.52 （95% CI: 0.29-0.94）和0.49 （95% CI: 0.3 -0.77）。此外。在两种疾病中，剂量-反应关系与饮用绿茶的年数有关。研究结果进一步支持了绿茶对胃癌的保护作用。这是第一次发现饮用绿茶对慢性胃炎有保护作用，这可能对设计高风险人群胃癌及其癌前病变的干预策略具有重要意义，(C) 2001 Wiley-Liss, Inc。
Despite the declining trend, stomach cancer remains the second most common cancer worldwide. We examined the role of green tea consumption on chronic gastritis and stomach cancer risks. A population-based case-control study was conducted in Yangzhong, China, with 133 stomach cancer cases, 166 chronic gastritis cases, and 433 healthy controls. Epidemiologic data were collected by standard questionnaire and odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models in SAS. Inverse association was observed between green tea drinking and chronic gastritis and stomach cancer risks. After adjusting for age, gender, education, body mass index, pack-years of smoking and alcohol drinking, ORs of green tea drinking were 0.52 (95% CI: 0.29-0.94) and 0.49 (95% CI: 0.3 1-0.77) for stomach cancer and chronic gastritis, respectively. in addition. dose-response relationships were observed with years of green tea drinking in both diseases. The results provide further support on the protective effect of green tea against stomach cancer. This is the first time that green tea drinking was found to be protective against chronic gastritis, which may be of importance when designing intervention strategies for stomach cancer and its pre-malignant lesions in the high-risk population, (C) 2001 Wiley-Liss, Inc.