Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, and nitrosodimethylamine
Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, and nitrosodimethylamine
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DOI：
10.1080/01635580701649636
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发表时间：
2008-03-01
影响因子：
2.9
通讯作者：
Martin, Nimit
中科院分区：
文献类型：
--
作者：
Mitacek, Eugene J.;Brunnemann, Klaus D.;Martin, Nimit
我们的工作假设是，泰国北部和东北部肝癌和胃癌的高发病率与硝酸盐、亚硝酸盐和亚硝基二甲胺（NDMA）的每日膳食摄入量增加有关。从1988年至1996年和1998年至2005年，系统地收集和分析了新鲜和腌制的泰国食品样品。在1998年至2005年期间，根据向467名成年人（212名男性和255名女性）发出的饮食问卷，确定了各种食物的消费频率。收集前一年和本年度的食物消费数据，并计算硝酸盐、亚硝酸盐和NDMA的摄入量（天、周和月）。将泰国四个地区肝癌和胃癌年龄标准化发病率（ASR）的趋势与这些相同地理区域的硝酸盐，亚硝酸盐和NDMA的饮食摄入量进行了比较。平均每日硝酸盐摄入量为155.7 mg/kg，亚硝酸盐为7.1 mg/kg，NDMA为1.08 μ g/kg/day，泰国各地区之间的膳食硝酸盐、亚硝酸盐和NDMA摄入量存在显著差异（P < 0.0001），这些差异对应于各地区之间肝癌和胃癌ASR值的变化。饮食因素可能在泰国肝癌和胃癌发生的不同阶段发挥关键作用。
It is our working hypothesis that the high rate of the liver and gastric cancers in North and Northeast Thailand is associated with increased daily dietary intake of nitrate, nitrite, and nitrosodimethylamine (NDMA). Samples of fresh and preserved Thai foods were systematically collected and analyzed from 1988 to 1996 and from 1998 to 2005. Consumption frequencies of various food items were determined on the basis of a dietary questionnaire given to 467 adults (212 males and 255 females) from 1998 to 2005. Food consumption data for the preceding and current year were collected and intakes (day, week, and month) of nitrate, nitrite, and NDMA were calculated. The trends in liver and stomach cancer age-standardized incidence rates (ASR) in four regions of Thailand were compared with the dietary intake of nitrate, nitrite, and NDMA in those same geographic regions. Mean daily intakes of nitrate of 155.7 mg/kg, of nitrite of 7.1 mg/kg, and of NDMA of 1.08 mu g/kg per day were found. Significant differences in dietary nitrate, nitrite, and NDMA intakes were seen between various Thai regions (P < 0.0001), and these corresponded to the variations in liver and stomach cancer ASR values between the regions. Dietary factors are likely to play key roles in different stages of liver and stomach carcinogenesis in Thailand.