Melatonin administration does not affect isoproterenol-induced LVH.
Melatonin administration does not affect isoproterenol-induced LVH.
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服用褪黑激素不会影响异丙肾上腺素诱导的 LVH。
DOI：
10.1109/memb.2006.1636358
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Garner,HaroldR
中科院分区：
文献类型：
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作者：
Flood,ElizabethM;Kumar,RobertS;Shah,Rashmi;Amos,Quinlan;Wren,JonathanD;Shohet,RalphV;Garner,HaroldR
左心室肥厚（LVH）是高血压的常见后遗症，与心源性猝死的发生率增加有关。本文报道的研究测量了在用异丙肾上腺素直接刺激心肌细胞的情况下褪黑激素对心脏的影响，从而最大限度地减少视交叉上核（SCN）自主神经输出的作用，并阐明褪黑激素对 LVH（慢性高血压的一种结果）的影响。结果表明，在异丙肾上腺素引起的肥大情况下，每日注射高剂量褪黑激素不会影响心脏重量：体重或心脏重量：胫骨长度比，这表明其他人观察到的褪黑激素对心血管的影响主要不是由于褪黑激素对心肌细胞的直接影响，而是由于另一种机制，可能是褪黑激素对 SCN 输出的调节。褪黑素对异丙肾上腺素诱导的 LVH 没有影响，表明其心血管作用并非由于对心肌细胞的直接影响所致。研究发现褪黑激素对高血压有显着疗效；然而，在这项研究中，即使在化学诱导的肥大小鼠模型中使用非常大剂量的褪黑激素，长期高血压的影响——心脏肥大（最终导致心力衰竭）也没有受到影响。有人认为，褪黑激素对高血压的作用与普通抗高血压药物相当。
Left ventricular hypertrophy (LVH), a common sequella of hypertension, is associated with increased incidence of sudden cardiac death. The study reported herein measured the effect of melatonin on the heart in the setting of direct cardiac myocyte stimulation with isoproterenol, thus minimizing the role of autonomic output from the suprachiasmatic nucleus (SCN) and clarifying the effect of melatonin on LVH, an outcome of chromic hypertensions. Results show that daily injections of high dosages of melatonin do not affect heart weight:body weight or heart weight:tibia length ratios in the setting of isoproterenol-induced hypertrophy, suggesting that the cardiovascular effects of melatonin observed by others are not due primarily to a direct effect of melatonin on cardiac myocytes but to another mechanism, possibly melatonin modulation of SCN output. Melatonin has no effect on isoproterenol-induced LVH, suggesting that its cardiovascular effects are not due to a direct effect on cardiac myocytes. Melatonin has been found to have a significant effect on hypertension; however, in this study, one effect of extended hypertension, cardiac hypertrophy, which can ultimately lead to cardiac failure, was not affected, even by very large doses of melatonin in a chemically induced hypertrophy mouse model. It has been suggested that the effect of melatonin on hypertension is comparable to common antihypertensive agents.