Genetic and shared environmental influences on children's 24-h food and beverage intake: sex differences at age 7 y
Genetic and shared environmental influences on children's 24-h food and beverage intake: sex differences at age 7 y
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DOI：
10.1093/ajcn/87.4.903
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发表时间：
2008-04-01
影响因子：
7.1
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Faith, Myles S.;Rhea, Sally Ann;Hewitt, John K.
背景资料：在幼儿期习惯性食物和饮料摄入的遗传学知之甚少。Objective：本研究的目的是测试遗传和环境对7岁儿童24小时食物和饮料摄入量的影响程度。特定食物-饮料类别的摄入量和儿童体重指数（13 MI;以kg/m2计）之间的关联也被测试。设计：采用经典的双胞胎设计，使用麦克阿瑟双胞胎纵向研究。共有792名儿童，其中396名男孩来自102个同卵双胞胎和96个异卵双胞胎对，396名女孩来自112个同卵双胞胎和86个异卵双胞胎对;儿童的24小时饮食摄入量估计由父母回忆，从9个复合食品饮料类别派生。将身高和体重转换为BMI。生物统计学分析的儿童每天摄入的食物，饮料类别和BMI进行了carried.Results：有一致的证据表明，遗传影响儿童的24小时摄入的食物和饮料（服务/天），特别是在男孩。有七个类别的遗传率在男孩中显示出显著性，从12%（鱼和柠檬）到79%（花生酱和果冻）不等。只有3个类别显示出女孩的遗传率估计值，从20%（面包和黄油）到56%（鱼和柠檬）不等。BMI表现出遗传相关性，仅与面包和黄油的摄入量在girls.Conclusion：遗传和环境的影响，对儿童的24小时的食物和饮料的摄入量的大小不同的男孩和女孩，这表明在饮食模式的发展中的性别差异。遗传力估计值通常很大，虽然其他饮食表型可能是必要的，以确定与肥胖的遗传相关性。
Background: The genetics of habitual food and beverage intake in early childhood is poorly understood.Objective: The objective was to test the magnitude of genetic and environmental influences on 24-h food and beverage intake in 7-yold children. The association between intake of specific food-beverage categories and child body mass index (13MI; in kg/m(2)) was also tested.Design: A classic twin design was conducted, using the MacArthur Longitudinal Study of Twins. There were 792 children, including 396 boys from 102 monozygotic and 96 dizygotic twin pairs and 396 girls from 112 monozygotic and 86 dizygotic twin pairs; Children's 24-h dietary intake was estimated by parental recall, from which 9 composite food-beverage categories were derived. Height and weight were converted to BMI. Biometrical analyses of children's daily intake of food-beverage categories and BMI were conducted.Results: There was consistent evidence of genetic influences on children's 24-h intake of food and beverages (servings/d), especially among boys. Seven categories showed significant heritability estimates among boys, ranging from 12% (fish and lemon) to 79% (peanut butter and jelly). Only 3 categories showed significant heritability estimates among girls, ranging from 20% (bread and butter) to 56% (fish and lemon). BMI showed a genetic correlation only with bread and butter intake in girls.Conclusion: The magnitude of genetic and environmental influences on children's 24-h food and beverage intake differed for boys and girls, which suggests sex differences in the development of eating patterns. Heritability estimates were generally large, although other eating phenotypes may be necessary for identifying genetic correlations with adiposity.