SEROEPIDEMIOLOGIC STUDIES OF CORONAVIRUS INFECTION INADULTS AND CHILDREN
SEROEPIDEMIOLOGIC STUDIES OF CORONAVIRUS INFECTION INADULTS AND CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a121171
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发表时间：
1970-01-01
影响因子：
5
通讯作者：
CHANOCK, RM
中科院分区：
文献类型：
--
作者：
MCINTOSH, K;APIKIAN, AZ;CHANOCK, RM
首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容(实验室。NIAID，NIH，贝塞斯达，马里兰州20014)成人和儿童冠状病毒感染的血清流行病学研究。描述了冠状病毒229E株、OC38株、OC43株和小鼠肝炎病毒(MHV)株A-59感染的血清流行病学研究。在患有上呼吸道疾病的成人中，发生了两次冠状病毒感染暴发，一次发生在1965-1966年冬季，与对OC38、OC43和MHV的补体固定(CF)抗体反应有关，另一次发生在次年冬季，与对229E的补体固定抗体反应有关。在住院儿童中，感染229E的情况很少见；患有下呼吸道疾病的住院儿童感染OC38、OC43和MHV的频率(3.5%)低于患有非呼吸道疾病的对照组(8.2%)。讨论了使用现有冠状病毒抗原进行CF检测的局限性。
McIntosh, K. A. Z. Kapikian, H. C Turner, J. W. Hartley, R. H. Parrott and R. M. Chanock. (Lab. of Infectious Diseases, NIAID, NIH, Bethesda, Md. 20014) Sero-epidemiologic studies of coronavirus infection in adults and children.Amer. J. Epid., 1970, 97: 585–592-A seroepidemiologic study of infection by coronavirus strains 229E, OC38, OC43, and mouse hepatitis virus (MHV) strain A-59, is described. In adults with upper respiratory disease, two “outbreaks” of coronavirus infection occurred, one during the winter of 1965–1966 associated with complement fixing (CF) antibody responses to OC38, OC43 and MHV, and the other during the following winter associated with CF antibody responses to 229E. In hospitalized children, infection with 229E was rare; infection with OC38, OC43, and MHV occurred less often in hospitalized children with lower respiratory tract disease (3.5%) than in a control group with non-respiratory tract disease (8.2%). The limitations of the CF test using available coronavirus antigens are discussed.