An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.
An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.
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DOI：
10.1097/dss.0000000000001048
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
Kelly KM
中科院分区：
文献类型：
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作者：
Soleymani T;Abrouk M;Kelly KM
皮肤癌仍然是美国最常见的癌症类型，其对医疗保健系统的负担仍然很大。冷冻手术、电热切除和刮宫、局部和光动力疗法以及包括莫氏显微手术在内的手术切除等标准治疗并非没有固有的发病率，包括出血、感染和疤痕的风险。激光可能是治疗非黑色素瘤皮肤癌的替代方法，本文回顾了这种治疗选择。对 Cochrane 图书馆、MEDLINE 和 PUBMED 数据库进行了全面检索，以确定研究激光疗法在非黑色素瘤皮肤癌治疗中的作用的相关文献。关于激光治疗非黑色素瘤皮肤癌的新文献不断涌现，证明了有希望的临床结果。血管选择性激光和烧蚀激光治疗基底细胞癌的效果最大。据报道，激光治疗鳞状细胞癌取得了一些成功，但数据缺乏说服力。总之，激光疗法为非黑色素瘤皮肤癌提供了另一种治疗选择。然而，其临床疗效参差不齐，目前仍低于目前公认的护理标准。需要进一步的研究来优化参数、确定最大功效并提供长期随访。
Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option. A comprehensive search in the Cochrane Library, MEDLINE, and PUBMED databases was performed to identify relevant literature investigating the role of laser therapy in the treatment of nonmelanoma skin cancer. New literature regarding laser treatment of nonmelanoma skin cancer is emerging, demonstrating promising clinical outcomes. The greatest efficacy has been seen with vascular-selective and ablative lasers in the treatment of basal cell carcinomas. Some success has been reported for laser treatment of squamous cell carcinoma, but data are less convincing. In summary, laser therapy offers an alternative treatment option for nonmelanoma skin cancer; however, its clinical efficacy is variable and, at this time, remains less than currently accepted standards of care. Further studies are needed to optimize parameters, determine maximum efficacy, and provide long-term follow-up.