Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy
Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy
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DOI：
10.1007/s12274-016-1332-2
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发表时间：
2017-03-01
期刊：
影响因子：
9.9
通讯作者：
Dong, Xiaochen
中科院分区：
文献类型：
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作者：
Cai, Yu;Si, Weili;Dong, Xiaochen
采用简单的再沉淀法制备了具有给体-受体-给体结构的有机小分子二酮吡咯并吡咯（SDPP）纳米粒。这些近红外辐射吸收NP具有高光热转换效率，并且能够通过增强的渗透性和保留效应选择性地靶向癌组织。得益于这些优点，SDPP纳米颗粒可以作为一种优秀的治疗剂，用于高效和无创的光声成像引导光热治疗。使用小鼠肿瘤模型的实验表明，SDPP NP在激光照射（660 nm，1.0 W中心点cm（aEuro-2））下，甚至在低剂量（0.16 mg中心点kg（aEuro-1））下也表现出优异的肿瘤消融能力。
Therapeutic nanoparticles (NPs) based on the donor-acceptor-donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W center dot cm(aEuro'2)), even at a low dose (0.16 mg center dot kg(aEuro'1)).