The chicken model of spontaneous ovarian cancer.
The chicken model of spontaneous ovarian cancer.
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DOI：
10.1002/prca.201300135
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Hawkridge AM
中科院分区：
文献类型：
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作者：
Hawkridge AM
鸡是研究卵巢癌（OVC）自发性发病和进展的独特实验模型。鸡中OVC的患病率范围为10-35%，取决于年龄，遗传株，生殖史和饮食。此外，鸡呈现出与人类OVC相似的流行病学，形态学和分子特征，使其成为翻译研究的相关实验模型。与人类的相似之处包括与排卵次数相关的OVC风险增加，常见的组织病理学亚型，包括高级别浆液性和分子水平的标志物或途径，如CA-125表达和p53突变频率。总的来说，鸡和人OVC之间的相似性结合严格控制的遗传背景和可预测的发病窗口提供了一个出色的实验模型，用于研究在受控环境条件下自发性OVC肿瘤的早期事件和进展。本综述将涵盖有关鸡OVC的现有文献，并强调进一步开发的潜在机会（例如生物标志物、预防、治疗和基因组学）。
The chicken is a unique experimental model for studying the spontaneous onset and progression of ovarian cancer (OVC). The prevalence of OVC in chickens can range from 10–35% depending on age, genetic strain, reproductive history, and diet. Furthermore, the chicken presents epidemiological, morphological, and molecular traits that are similar to human OVC making it a relevant experimental model for translation research. Similarities to humans include associated increased risk of OVC with the number of ovulations, common histopathological sub-types including high-grade serous, and molecular-level markers or pathways such as CA-125 expression and p53 mutation frequency. Collectively, the similarities between chicken and human OVC combined with a tightly controlled genetic background and predictable onset window provides an outstanding experimental model for studying the early events and progression of spontaneous OVC tumors under controlled environmental conditions. This review will cover the existing literature on OVC in the chicken and highlight potential opportunities for further exploitation (e.g, biomarkers, prevention, treatment, and genomics).