Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications
Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications
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DOI：
10.1021/acs.molpharmaceut.5b00358
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发表时间：
2015-10-01
影响因子：
4.9
通讯作者：
Vicent, Maria J.
中科院分区：
文献类型：
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作者：
Duro-Castano, Aroa;England, Richard M.;Vicent, Maria J.
由于没有可用于治疗所有疾病的通用聚合物系统，因此需要开发新的和创新的聚合物载体来用作药物递送系统和/或显像剂。此外，现有系统的局限性，例如缺乏生物降解性和生物相容性，不可避免地会导致副作用和患者依从性差。基于氨基酸的新型聚合物疗法是药物输送的绝佳候选者，因为它们不受这些限制。本文报道了一种简单而强大的合成三臂星形聚谷氨酸的方法，该聚谷氨酸具有明确的结构、精确的分子量 (MW) 和低多分散性 (D =
There is a need to develop new and innovative polymer carriers to be used as drug delivery systems and/or imaging agents owing to the fact that there is no universal polymeric system that can be used in the treatment of all diseases. Additionally, limitations with existing systems, such as a lack of biodegradability and biocompatibility, inevitably lead to side effects and poor patient compliance. New polymer therapeutics based on amino acids are excellent candidates for drug delivery, as they do not suffer from these limitations. This article reports on a simple yet powerful methodology for the synthesis of 3-arm star-shaped polyglutamic acid with well-defined structures, precise molecular weights (MW), and low polydispersity (D =