Serotonin and the search for the anatomical substrate of aggression
Serotonin and the search for the anatomical substrate of aggression
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DOI：
10.1080/19336934.2015.1045171
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发表时间：
2014-10-02
期刊：
影响因子：
1.2
通讯作者：
Kravitz, Edward A.
中科院分区：
文献类型：
--
作者：
Alekseyenko, Olga V.;Kravitz, Edward A.
所有种类的动物都表现出侵略性，以获得资源，如领土，配偶或食物。适当的攻击性表现依赖于对潜在竞争者的正确识别、对环境信号的评估以及动物的生理状态。通过固定数量神经元的硬连线电路，像血清素这样的神经调节剂在不改变“硬连线”的情况下提供了行为反应的适应性灵活性。在最近的一份报告中，我们结合了交叉遗传学，定量行为分析和形态学分析，以确定单一的多巴胺能神经元，调节侵略的升级。我们发现了大脑中的解剖目标区域，这些神经元似乎与表达5HT1A受体的神经元形成突触接触，然后在功能水平上证实了这些连接的可能性。在这篇Extra View文章中，我们对这些最新发现进行了深入讨论，并详细阐述了它们如何在单细胞分辨率水平上将攻击调节电路的细胞和功能映射联系起来。
All species of animals display aggression in order to obtain resources such as territories, mates, or food. Appropriate displays of aggression rely on the correct identification of a potential competitor, an evaluation of the environmental signals, and the physiological state of the animal. With a hard-wired circuitry involving fixed numbers of neurons, neuromodulators like serotonin offer adaptive flexibility in behavioral responses without changing the “hard-wiring”. In a recent report, we combined intersectional genetics, quantitative behavioral assays and morphological analyses to identify single serotonergic neurons that modulate the escalation of aggression. We found anatomical target areas within the brain where these neurons appear to form synaptic contacts with 5HT1A receptor-expressing neurons, and then confirmed the likelihood of those connections on a functional level. In this Extra View article, we offer an extended discussion of these recent findings and elaborate on how they can link a cellular and functional mapping of an aggression-regulating circuit at a single-cell resolution level.