Differential effect of double-pulse TMS applied to dorsal premotor cortex and precuneus during internal operation of visuospatial information
Differential effect of double-pulse TMS applied to dorsal premotor cortex and precuneus during internal operation of visuospatial information
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DOI：
10.1016/j.neuroimage.2009.07.034
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Honda, Manabu
中科院分区：
文献类型：
--
作者：
Oshio, Ritz;Tanaka, Satoshi;Honda, Manabu
人类的神经影像学研究经常报道在视觉空间信息的内部操作过程中，背侧运动前皮层（PMd）和后顶叶皮层（PPC）的共同激活，这里称为“视觉空间心理操作”。然而，在这些任务中分配给项目经理和项目执行主任的职能仍然不清楚。在这里，我们研究的意义，这两个领域的视觉空间的心理操作使用经颅磁刺激（TMS）技术。受试者执行一项任务，其中视觉空间的心理操作是必需的。在TMS实验之前，使用功能磁共振成像（fMRI）进行的定位研究表明，PMd和PPC的内侧部分，楔前叶（PCu），在视觉空间心理操作过程中被特异性激活。然后，我们在同一任务中使用双脉冲TMS来阻止右半球的PMd和PCu的活动，以确定这些活动是否是任务所必需的。根据视觉空间心理操作线索，在不同时间应用TMS。因此，只有在提示后300 ms应用的TMS影响任务性能。此外，我们发现，TMS在这个时候，每个领域的差异影响的性能：TMS的PMd阻碍了性能的任务，而TMS的PCU促进它没有速度/准确性的权衡。这些影响在缺乏视觉空间心理操作的控制条件下没有发现。这些研究结果表明，PMd和PCU参与视觉空间心理操作的不同方面。(C)2009 Elsevier Inc. All rights reserved.
Human neuro-imaging studies have often reported co-activation of the dorsal premotor cortex (PMd) and the posterior parietal cortex (PPC) during internal operation of visuospatial information, referred to here as "visuospatial mental operation". However, the functions assigned to the PMd and PPC during these tasks are still unclear. Here, we examined the significance of these two areas for a visuospatial mental operation using the transcranial magnetic stimulation (TMS) technique. Subjects performed a task in which a visuospatial mental operation was required. A localization study conducted prior to the TMS experiment using functional magnetic resonance imaging (fMRI) revealed that the PMd and the medial part of the PPC, precuneus (PCu), were specifically activated during the visuospatial mental operation. Then, we impeded the activities of the PMd and the PCu in the right hemisphere during the same task using double-pulse TMS to determine whether these activities were necessary for the task. The TMS was applied at different times in relation to the visuospatial mental operation cue. Consequently, only the TMS applied at 300 ms after the Cue affected the task performance. Furthermore, we found that the TMS at this time to each area differentially affected the performance: TMS to the PMd hindered the performance of the task whereas TMS to the PCu facilitated it without a speed/accuracy trade-off. These effects were not found in the control condition that lacked a visuospatial mental operation. These findings suggest that the PMd and the PCu are involved in differential aspects of visuospatial mental operations. (C) 2009 Elsevier Inc. All rights reserved.