Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats.
Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats.
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膳食中富含γ-亚麻酸的油可降低大鼠体内脂肪含量并诱导与脂肪酸β-氧化相关的肝酶活性。
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
T. Mori
中科院分区：
文献类型：
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作者：
R. Takada;M. Saitoh;T. Mori
本研究的目的是检验从真菌中提取的富含γ - 亚麻酸的油脂对大鼠身体组成以及肝脏中与脂肪代谢相关的各种酶活性的影响。该油脂含25.3克γ - 亚麻酸/100克脂肪酸。饲料中富含γ - 亚麻酸的油脂水平分别为0、1.5和4%，即每千克饲料中含0、2.88和7.68克γ - 亚麻酸。对照饲料含8%的大豆油。大鼠自由进食这些饲料4周。尽管三组的食物摄入量相似，但喂食γ - 亚麻酸油脂组的体重增加量少于对照组。喂食γ - 亚麻酸油脂组的胴体绝对脂肪重量和相对脂肪重量均显著低于对照组。三组的胴体蛋白质和水分含量没有差异，不过当以体重为参照表示时，喂食γ - 亚麻酸组的值略高于对照组。喂食γ - 亚麻酸油脂组的血浆总胆固醇和游离脂肪酸浓度通常低于对照组。在肝脏中，三组之间苹果酸酶和柠檬酸裂解酶的活性没有显著差异。然而，喂食γ - 亚麻酸油脂组的肉碱棕榈酰转移酶和过氧化物酶体β - 氧化活性显著高于对照组。这些结果清楚地表明，膳食中的γ - 亚麻酸油脂可降低身体脂肪含量，并促进肝脏中的脂肪酸β - 氧化。
The objectives of this study were to examine the effects of dietary gamma-linolenic acid-enriched oil extracted from fungi on rat body composition and on the various enzyme activities relating to fat metabolism in the liver. The oil contained 25.3 g gamma-linolenic acid/100 g fatty acids. The levels of gamma-linolenic acid-enriched oil in the diets were 0, 1.5 and 4%, to give 0, 2.88 and 7.68 g gamma-linolenic acid/kg diet. The control diet contained 8% soybean oil. The rats were given free access to these diets for 4 wk. Body weight gain was less in the gamma-linolenic acid oil-fed groups than in the control group, although food intake was similar among the three groups. Absolute and relative carcass fat weights were significantly lower in the gamma-linolenic acid oil-fed groups than in the control group. Carcass protein and water contents were not different among the three groups, although values were slightly greater than controls in gamma-linolenic acid-fed groups when expressed relative to body weight. Plasma total cholesterol and free fatty acid concentrations generally were lower in the gamma-linolenic acid oil-fed groups than in the control group. In the liver, there were no significant differences in activities of malic enzyme and citrate cleavage enzyme among the three groups. However, the activities of carnitine palmitoyl-transferase and peroxisomal beta-oxidation were significantly higher in the gamma-linolenic acid oil-fed groups than in the control group. These results clearly demonstrate that dietary gamma-linolenic acid oil reduces body fat content and facilitates fatty acid beta-oxidation in the liver.